About this Research Topic
Metabolic reprogramming is a hallmark of cancer. Compared to normal cells, cancer cells undergo metabolic reprogramming to support their proliferation, metastasis and survival. Several oncogenic signaling pathways play an important role in cancer metabolism. Alteration of enzymes like HK2, PKM2, GLS1, IDH and SHMT2 is involved in cancer metabolic reprogramming. Recently, growing evidence indicates that long non-coding RNAs (lncRNAs) play an important role in regulating cancers in many aspects including tumor cell metabolism. LncRNAs are mRNA-like transcripts that are longer than 200 nucleotides, yet do not appear to encode a protein. Many lncRNAs are differentially expressed between a variety of cancer tissues and corresponding para-cancer tissues, and their dysregulation has been connected to carcinogenesis and tumor progression. LncRNAs exert their function through miRNAs or directly through targeting metabolic reprogramming related kinases. Exploring the roles and mechanisms of lncRNAs in the regulation of cancer metabolism can contribute to a better understanding of cancer progression mechanisms and the discovery of novel therapeutic targets.
The objective of this Research Topic is to give a comprehensive overview of the regulatory role of lncRNA in cancer metabolism in the context of proliferation, apoptosis, metastasis, autophagy, and resistance to therapy in different cancers. We welcome Original Research, Reviews, and Mini-Review articles focusing on but not limited to the following topics:
1) Regulatory roles of lncRNAs in tumor-related metabolic reprogramming.
2) LncRNAs dysregulation in cancer cells, exosomes and cancer-related immune cells.
3) LncRNAs as the regulator of glucose, amino acid and lipid metabolism of cancer cells.
4) LncRNAs as a regulator of mitochondrial function in cancer cells.
5) LncRNAs and autophagy in cancer metabolism.
Keywords: lncRNA, cancer, metabolic reprogramming, glucose, amino acids, metabolism
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