Research Topic

Cellular Mechanisms during Normal and Abnormal Craniofacial Development

About this Research Topic

Embryonic craniofacial development involves a succession of cellular processes driving patterning, outgrowth, and fusion of a number of independently forming components. The progression of growth and morphogenesis relies on cellular mechanisms such as differentiation, proliferation, migration, transformation, and apoptosis to form the correct shape and structure in the developing embryo. During craniofacial development, the aforementioned processes are constrained spatiotemporally, allowing for multiple mechanisms within a relatively small region, in order to create complex and intricate structures. Failure at any stage risks considerable effects on the embryo, ranging from slight defects in craniofacial patterning to total deformity.

The current Research Topic intends to examine and collate the most up to date studies on the cellular processes that drive embryonic craniofacial morphogenesis. In recent years, scientists have taken great strides towards attaining a better understanding of the cellular mechanisms involved in the fundamental aspects of craniofacial development. Seemingly disparate fields such as computer sciences, mathematics, tomographic and microscopic imaging, biochemistry, and molecular biology have come together to greatly enhance our understanding on how individual cells influence overall patterning and morphogenesis of the embryonic face.

We welcome Original Research, Reviews, as well as Opinion papers with the aim of consolidating recent findings on the topic of cellular mechanisms involved in embryonic craniofacial morphogenesis. The subtopics to be covered include, but are not limited to:

• Signal transduction and mechanotransduction
• Differentiation
• Proliferation
• Migration
• Transformation
• Apoptosis
• Non-Apoptotic cellular necrosis
• Technological advances in imaging of embryonic morphogenesis


Keywords: Embryo, Gene Expression, Morphogenesis, Embryonic Patterning, Development


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Embryonic craniofacial development involves a succession of cellular processes driving patterning, outgrowth, and fusion of a number of independently forming components. The progression of growth and morphogenesis relies on cellular mechanisms such as differentiation, proliferation, migration, transformation, and apoptosis to form the correct shape and structure in the developing embryo. During craniofacial development, the aforementioned processes are constrained spatiotemporally, allowing for multiple mechanisms within a relatively small region, in order to create complex and intricate structures. Failure at any stage risks considerable effects on the embryo, ranging from slight defects in craniofacial patterning to total deformity.

The current Research Topic intends to examine and collate the most up to date studies on the cellular processes that drive embryonic craniofacial morphogenesis. In recent years, scientists have taken great strides towards attaining a better understanding of the cellular mechanisms involved in the fundamental aspects of craniofacial development. Seemingly disparate fields such as computer sciences, mathematics, tomographic and microscopic imaging, biochemistry, and molecular biology have come together to greatly enhance our understanding on how individual cells influence overall patterning and morphogenesis of the embryonic face.

We welcome Original Research, Reviews, as well as Opinion papers with the aim of consolidating recent findings on the topic of cellular mechanisms involved in embryonic craniofacial morphogenesis. The subtopics to be covered include, but are not limited to:

• Signal transduction and mechanotransduction
• Differentiation
• Proliferation
• Migration
• Transformation
• Apoptosis
• Non-Apoptotic cellular necrosis
• Technological advances in imaging of embryonic morphogenesis


Keywords: Embryo, Gene Expression, Morphogenesis, Embryonic Patterning, Development


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

25 June 2020 Abstract
23 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

25 June 2020 Abstract
23 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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