Research Topic

Importance of nutrient acquisition and metabolic adaptation in intracellular bacterial parasitism.

  • Submission closed.

About this Research Topic

In order to develop a successful infectious process, intracellular bacterial pathogens must be able to utilize optimally the nutrients available in the cellular compartment where they reside and adapt their metabolism to this peculiar environment. Depending on their host cell(s) and infectious cycle, ...

In order to develop a successful infectious process, intracellular bacterial pathogens must be able to utilize optimally the nutrients available in the cellular compartment where they reside and adapt their metabolism to this peculiar environment. Depending on their host cell(s) and infectious cycle, intracellular bacteria have evolved very distinct strategies. For example, obligate intracellular pathogens must possess specific nutrient acquisition attributes as when compared to facultative intracellular pathogens. Similarly, pathogens able to persist chronically present specific adaption capacities as compared to pathogens residing only transiently intracellularly. Some bacteria are able to invade and multiply in a broad variety of cells, including professional phagocytes and non-phagocytic cell, probably reflecting a broad panel of nutritional attributes and efficient metabolic adaptation. Finally, tissue and host tropism are also likely to rely on bacterial nutritional and metabolic adaptation.
Remarkably, all the recent genome wide screens revealed that an important proportion of the genes involved in intracellular survival and virulence were related to metabolic and nutritional functions. However, the relationship between nutrition and the life cycle of intracellular bacteria is yet poorly understood.
This Research Topic will examine the different strategies developed by intracellular bacteria to survive nutritional starvation. Given examples of bacteria were selected, which are distributed in distinct intracellular niches.
Articles will focus on the most recent findings regarding the molecular mechanisms adapted by these bacteria to cope with the harsh intracellular environment of infected host cells.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top