Research Topic

Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis and evolution

About this Research Topic

Enteropathogenic and enterohemorrhagic E. coli are important causes of gastrointestinal disease worldwide. As part of their pathogenesis, EPEC and EHEC cause a distinctive lesion on the intestinal mucosa known as an attaching and effacing (A/E) lesion. A/E lesion formation requires a type III secretion ...

Enteropathogenic and enterohemorrhagic E. coli are important causes of gastrointestinal disease worldwide. As part of their pathogenesis, EPEC and EHEC cause a distinctive lesion on the intestinal mucosa known as an attaching and effacing (A/E) lesion. A/E lesion formation requires a type III secretion system that injects multiple effector proteins into the cell. Despite their shared mechanism of intestinal colonization, EPEC and EHEC exhibit substantial differences in epidemiology and clinical disease. In particular, EHEC produces a potent Shiga toxin that is associated with development of the haemolytic uremic syndrome (HUS), an acute form of renal failure. This Research Topic will examine interactions between attaching and effacing bacteria and the host cell, and discuss EPEC/EPEC ecology, genomics and animal models of disease. Articles will centre on pathogen evolution, novel adhesins, type III effector biology and bacterium-host responses during infection.

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Abstract Submission Deadline: November 15, 2011
Full Article Submission Deadline: January 1, 2011


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