Research Topic

Sex differences in the inflammatory response among cardiovascular disease patients

About this Research Topic

Inflammatory processes are not only known to play a key role in the development of cardiovascular disease, including atherosclerosis, cardiomyopathies and heart failure, they are also crucially involved in auto-immune diseases. This might explain why cardiovascular disease is more prevalent in patients with autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Moreover, autoimmune diseases are more common in females and it has been postulated that females recover better and faster upon infection or trauma.
The cause of the increased cardiovascular disease risk in chronic inflammatory disease patients is multifactorial, and has been associated with the presence of autoantibodies which contribute to a pro-thrombotic environment and a vulnerable atherosclerotic plaque phenotype. Moreover, low grade chronic inflammation, mostly associated with the presence of comorbidities, has been postulated as a key driver in adverse cardiac remodeling and the development of heart failure. Currently, not very much is known on the sex differences in inflammatory responses among cardiovascular disease patients and how these differences are associated with cardiovascular disease burden and risk for clinical presentation.
The scope of the Research Topic is to present and discuss the role of sex in inflammatory responses in cardiovascular disease patients. Better understanding the gender aspects in vascular disease (i.e. atherosclerosis, aneurysms), cardiomyopathies and heart failure development in both the general as well as high risk populations (i.e. autoimmune patients) is needed to improve treatment options and reduce cardiovascular disease burden for both male and female patients.

We are interested in manuscripts that describe the role of sex on pathophysiology, epidemiology, etiology, diagnosis, therapies, and prognosis of cardiovascular disease. We welcome fundamental and clinical work, Original Research, Reviews, new Methodology papers, and Systematic Reviews/meta-analyses.


Keywords: atherosclerosis, heart failure, autoimmune disease, inflammation, sex


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Inflammatory processes are not only known to play a key role in the development of cardiovascular disease, including atherosclerosis, cardiomyopathies and heart failure, they are also crucially involved in auto-immune diseases. This might explain why cardiovascular disease is more prevalent in patients with autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Moreover, autoimmune diseases are more common in females and it has been postulated that females recover better and faster upon infection or trauma.
The cause of the increased cardiovascular disease risk in chronic inflammatory disease patients is multifactorial, and has been associated with the presence of autoantibodies which contribute to a pro-thrombotic environment and a vulnerable atherosclerotic plaque phenotype. Moreover, low grade chronic inflammation, mostly associated with the presence of comorbidities, has been postulated as a key driver in adverse cardiac remodeling and the development of heart failure. Currently, not very much is known on the sex differences in inflammatory responses among cardiovascular disease patients and how these differences are associated with cardiovascular disease burden and risk for clinical presentation.
The scope of the Research Topic is to present and discuss the role of sex in inflammatory responses in cardiovascular disease patients. Better understanding the gender aspects in vascular disease (i.e. atherosclerosis, aneurysms), cardiomyopathies and heart failure development in both the general as well as high risk populations (i.e. autoimmune patients) is needed to improve treatment options and reduce cardiovascular disease burden for both male and female patients.

We are interested in manuscripts that describe the role of sex on pathophysiology, epidemiology, etiology, diagnosis, therapies, and prognosis of cardiovascular disease. We welcome fundamental and clinical work, Original Research, Reviews, new Methodology papers, and Systematic Reviews/meta-analyses.


Keywords: atherosclerosis, heart failure, autoimmune disease, inflammation, sex


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 May 2021 Manuscript

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Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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