Research Topic

Cell-Cell Interactions Controlling Neuronal Functionality in Health and Disease

About this Research Topic

Neuronal cells are an essential component of the mammalian central nervous system (CNS), equipped with the unique capabilities of decoding the signals associated with sensory stimuli and controlling body movement and cognition. The activity of neurons is regulated at multiple levels in physiologic conditions ...

Neuronal cells are an essential component of the mammalian central nervous system (CNS), equipped with the unique capabilities of decoding the signals associated with sensory stimuli and controlling body movement and cognition. The activity of neurons is regulated at multiple levels in physiologic conditions and depends on their interaction with CNS resident microglia, astrocytes, and oligodendrocytes, as well as on the flux of nutrients through the blood-brain barrier (BBB). However, detrimental events may compromise the CNS milieu and cytoarchitecture, and affect essential neuronal activities, ultimately causing neuronal death, loss of motor functions, cognitive decline, and systemic body failure.

In this Research Topic, we aim at providing a collection of high-impact papers dissecting how neurons directly or indirectly interact with CNS resident cells, endothelial cells of the BBB, and infiltrating immune cells in health and disease, from prenatal to adult life. The Research Topic will be developed in close collaboration with the scientific committee of the BraYn conference (https://www.braynconference.com/), and will cover the themes discussed at the meeting:

- Neurophysiology and neural plasticity
- Pediatric neuroscience and perinatal neurology
- Neuro-oncology
- Neuroinflammation
- Neurodegeneration

Accordingly, Original Research or Review articles describing how this crosstalk influences physiologic functions such as neuronal development and neuronal plasticity in steady-state conditions will be considered. Moreover, manuscripts reporting how this network of interactions is dysregulated in pathological processes such as the development of CNS tumors, neuroinflammation, and neurodegeneration are welcome. The final goal of this Research Topic will be to update our knowledge on the complex structure of cell-cell communication essential for proper neuronal development, activity, and survival.


Keywords: neurophysiology, neural plasticity, neuroinflammation, neurooncology, pediatric neuroscience, perinatal neurology, neurodegeneration


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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