About this Research Topic
The tissue niche is a double blade for stem cell fate determination and cancer reprogramming. Niche factors such as oxygen tension, endocrinal growth factors, extracellular matrix, mesenchymal fibroblast, and immune environment play critical roles in the expressions of stemness-related genetic/epigenetic genes. Dysregulation of these niche factors in tissues often leads to malignant tumor formation, tumor metastasis, drug resistance, and early tumor relapse which challenge the current therapeutic efficacy. Additionally, in stem cell therapy, the culture niche will dominantly affect the stem cell properties which control the stem cell safety and efficacy in clinical precision medicine.
The goal of this Research Topic is to advance our understanding in the relationship between the niche signals regulating stem cell fate determination during embryonic development and the reprogramming of cancer cells. Therapeutic targeting niche factors will help with the safety and efficacy for future advanced cancer treatment and unmet needs.
The aim of the current Research Topic is to cover promising, recent, and novel research trends in the dialogues between tissue niche and stem cell fate determination or cancer reprogramming. Areas to be covered in this Research Topic may include, but are not limited to:
• Biology niche and embryonic pluripotency regulation
• Inflammatory niche and cancer reprogramming, metastasis, drug resistance, and
early tumor relapse
• Cancer stemness: Cancer stem cells or cancer reprogramming?
• Niche and epigenetic regulation in embryonic pluripotency and cancer reprogramming
• Niche and metabolism regulation in embryonic pluripotency and cancer reprogramming
• Switching niche signaling dialogue between embryonic pluripotency and cancer
• Niche factors and therapeutic strategies
• Culture niche and stem cell properties: Safety and efficacy in stem cell therapy
Keywords: Microenvironment, embryonic pluripotency, cancer reprogramming, epigenetics, therapeutics therapeuticsapplications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.