Research Topic

Adverse and Toxic Effects of Childhood Cancer Treatments

About this Research Topic

Over the past several decades, increased survival for childhood cancer has become a reality due the improvements of multimodal treatments. Survival rates have increased and many children are becoming long-term survivors of cancer. Nevertheless, these children carry a potential risk of significant side effects ...

Over the past several decades, increased survival for childhood cancer has become a reality due the improvements of multimodal treatments. Survival rates have increased and many children are becoming long-term survivors of cancer. Nevertheless, these children carry a potential risk of significant side effects which may result in multiorgan impairment and deterioration of their quality of life. Side effects of commonly used pediatric cancer treatment, such as chemotherapy, can include nausea, vomiting, mucositis, cardiotoxicity, neurocognitive impairment, neuropathy, musculoskeletal morbidity, and endocrine dysfunction. The onset of these side effects can be acute or chronic, having the potential to result in a severe disabling, life-threatening or fatal illness, such as a cardiovascular disease, stroke, pulmonary fibrosis, kidney failure, or even a second malignancy.

Studies are needed to integrate emerging information on patient susceptibility and treatment
with established clinical risk factors. Novel interventions aimed at reducing acute side effects, as well as the long-term burden on survivors who are at most risk from treatment related side effects, are also required. Multidisciplinary collaboration between primary care providers, oncologists, and other medical specialists is integral to the successful implementation of these interventions.

For this Research Topic, we would like to include Original Research and Review articles that focus on the pathophysiology, diagnosis, treatment, and outcomes of acute and long-term side effects in children treated for cancer. Topics will include both basic science and clinical research with a strong focus on, but not limited to, the following:

1. Emerging strategies in symptom management.
2. Impact of cancer treatment on children’s mental and social well-being.
3. Pediatric cardiac, cardiovascular, hearing, renal, and respiratory complications.
4. Pathophysiology of common side effects including nausea, vomiting, mucositis, endocrine system problems, and neurocognitive sequelae.
5. Childhood bone metabolism and health.


Keywords: Children, Chemotherapy, Cancer, Treatment, Sequelae


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

31 January 2021 Manuscript
31 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

31 January 2021 Manuscript
31 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..