Research Topic

Metabolic Alterations in Neurodegenerative Disorders

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About this Research Topic

Medical illnesses such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis fall under the umbrella of the definition of Neurodegenerative disorders (NDDs). They cause a progressive and irreversible deterioration of the brain, disturbing the daily activity of ...

Medical illnesses such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis fall under the umbrella of the definition of Neurodegenerative disorders (NDDs). They cause a progressive and irreversible deterioration of the brain, disturbing the daily activity of affected individuals.

Accumulating evidences suggest that these NDDs are intimately connected to metabolic alterations, which facilitate or trigger the progression of these diseases. Since the prevalence of patients suffering NDDs are increasing exponentially, a more profound understanding of the implications of these metabolic alterations associated to these NDDs is imperative. The dissection of novel molecular mechanisms underlying the pathological processes by which metabolic changes are associated with NDDs, can translate to promising therapeutic strategies that could prevent or modify the progression of these disorders.

The major goal in this Research Topic is to gather expertise in the field that provides novel evidence, mechanisms and approaches for a better understanding of the implications of metabolic alterations in the onset and progression of NDDs. Research findings, reviews, new insights and approaches are welcome in the following research areas:

- Role of metabolic changes in neuronal and glial cells and its implications to NDDs onset and progression.

- Cognitive and synaptic deficits associated to metabolic changes and NDDs.

- Protein propagation and seeding in metabolic disorders and NDDs.

- Metabolic-related alterations in the integrity of the blood brain barrier and its implications to NDDs.

- Clearance processes, such as proteasome or autophagy, as a bridge between metabolic alterations and NDDs.

- Novel approaches for modeling metabolic alterations in human neurons.

- Diagnostic and therapeutic strategies.


Keywords: Neurodegenerative Disorders, Metabolism


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