About this Research Topic
Genomic profiling has revealed the heterogeneity of gastrointestinal tumors, and the combination of inter-patient heterogeneity and intra-tumor heterogeneity was identified as a determining factor of tumor development. Molecular heterogeneity at multiple levels including genomics, epigenomics, transcriptomics, and microenvironment features conferring each patient variation in the response to anti-cancer therapies should be considered. Due to the heterogeneity of gastrointestinal cancers associated with different clinical biometrics, the prognosis of each patient is different. Therefore, more novel and effective anti-cancer therapeutic algorithms should be discussed to selected subsets of gastrointestinal tumors.
This Research Topic aims to provide a comprehensive overview of recent advances in the association between tumor heterogeneity and related anti-cancer therapies for gastrointestinal cancer. We welcome the submission of Review and Original Research articles covering, but not limited to, the following topics:
• Novel molecular mechanism research on the association between heterogeneity and related anti-cancer therapies for gastrointestinal tumors including gastric, colorectal, liver, pancreas, bile duct, and esophageal tumors.
• Novel clinical research focus on anti-cancer strategies derived from tumor heterogeneity studies for gastrointestinal cancer
• Novel therapeutic targets derived from tumor heterogeneity studies for gastrointestinal cancer
• Novel special heterogeneity biomarker to predict the anti-cancer treatment response and prognosis of gastrointestinal cancer
Keywords: Gastrointestinal Cancer, Heterogeneity, Molecular Target, Anti-Cancer Strategies
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