About this Research Topic
Nearly 100 years after the key discoveries in the cancer metabolism field, such as the Warburg effect and the Crabtree effect, we experience a renaissance of this topic. The latest discovery around the potential impact of autophagy in the context of oncogenesis was originated from the pioneering studies by Yoshinori Ohsumi for which he was awarded the 2016 Nobel Prize in Physiology/Medicine. These discoveries provide an unexpected link that ties together previously unrelated scientific fields.
The end of 20th century also brought us the understanding of the molecular mechanics that controls rapid regulation of cell adhesion and de-adhesion during cell homing recruitment, mobilization and rapid deployment of normal immune cells and their leukemic counterparts. In 2019, Timothy Springer was awarded the Canada Gairdner International Award for his work that lead to deciphering the molecular mechanisms responsible for these adhesion changes, namely integrin receptors. Today, accumulating evidence suggests that the regulation of the integrin-dependent cell adhesion could be operating under a control of cell metabolism, since the second messengers and signaling pathways that control cellular respiration, nucleotide synthesis and immune and cancer cell adhesion, migrations and metastasis show a great deal of similarity.
In this Research Topic, we welcome authors to contribute with Original Research and Review articles that will add to our continuing efforts to understand an intricate relationship between cell metabolism, respiration, autophagy, mitophagy, oncogenesis with cell adhesion and de-adhesion, aberrant adhesion and integrin regulation, as well as novel therapeutic strategies that will employ targeting aberrant cancer cell metabolism and adhesion.
Potential topics include, but are not limited to:
• Metabolic vulnerabilities in cancer
• Autophagy, mitophagy and mitochondria in cancer
• Aberrant adhesion and metabolism in cancer
• Cell adhesion, migration and metabolism (including normal immune and/or cancer cells)
• Signaling pathways/mechanisms that regulate metabolism and cell adhesion
• In vivo and in vitro models for studies on metabolism and cell adhesion including patient-derived xenografts (PDXs)
• Metabolic regulation of integrin-dependent adhesion
• Targeting aberrant cancer cell metabolism and adhesion
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.