About this Research Topic
Hematopoiesis is a dynamic process of formation and development of all types of blood cells to build up the blood and immune systems, which is tightly controlled by both genetic and epigenetic factors. Dysregulation of hematopoiesis is associated with hematologic diseases and immune system disorders. Understanding the hematopoietic regulatory mechanisms will not only improve our knowledge about hematopoiesis but also promote the diagnosis and treatment of blood diseases.
During the last decades, both in vitro and in vivo systems have been applied for studying hematopoiesis and have extensively unveiled the developmental processes of blood cells. Novel key hematopoietic regulators have been identified by classical forward and reverse genetics approaches, and our knowledge in hematopoiesis expands rapidly with the fast-developing technologies, such as gene editing, state-of-art imaging techniques, and multi-omics. Taking advantage of hematopoietic disease models, translational researches for developing therapeutic strategies are attracting more and more attention.
This Research Topic aims to present recent advances in the developmental processes and regulatory mechanisms involved in hematopoiesis. Especially, it welcomes the investigations on establishing new animal models or developing novel strategies for in-depth studies of hematopoiesis and hematological disorders.
We welcome the submission of Original Research, Methods, Review and Mini-Review articles that cover, but are not limited to, the following topics:
-Hematopoietic cell and functional blood cell development and regulation
-Animal models for hematopoiesis and hematologic disorders
-Reprograming and epigenetic regulation on hematopoiesis
-Hematopoiesis in stress, aging and regeneration
-New strategies in hematopoiesis
Keywords: Hematopoiesis, Animal models, Reprograming, epigenetic regulation
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