About this Research Topic
This Research Topic focuses on the research detailing the mechanisms and functions of therapeutic drug targets for SARS-CoV-2 infections, as well as the macromolecules responsible for the binding of the virion to the host receptor protein. Understanding the detailed pathophysiological mechanism during COVID-19 infections is of the utmost importance to develop an effective therapeutic intervention. Likewise, understanding the atomic insight of the macromolecules presented in the virion is important to combat the viral pandemic via the development of a vaccine. Revealing the pathological mechanisms and atomic information of the macromolecule will assist in the development of a novel agonist or antagonist which could become a primary drug candidate to treat this pandemic.
In this Research Topic, we welcome Original Research and Review articles. We will not be accepting studies based only on in silico data. We expect topics to cover, but are not limited to the following:
1. Mechanism of host proteins for the SARS-CoV-2 replication and maturation;
2. SARS-CoV-2 mutations in role of pathogenicity;
3. Cancer and diabetic drug target for SARS-CoV-2 protein -protein interactions;
4. Plant compounds as drug candidates to treat SARS-CoV-2 infections;
5. Study on antibody interactions with SARS-CoV-2 proteins;
6. Drug repurposing for the treatment of COVID-19;
7. Progression on drug screening for SARS-CoV-2 drug targets;
8. Structure-based modeling to identify critical residues.
Keywords: COVID-19, SARS-CoV-2, Structure-based drug designing, Molecular Docking, Molecular Dynamic Simulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.