Marine natural products are distinct by their structural diversity and unique chemical functionalization. Most compounds discovered in marine macro-organisms are detected in minute quantities, which demands significant amounts of biomass to generate sufficient compounds for industrial application. In most cases, this practice is significantly damaging fragile marine ecosystems, such as coral reefs. Today, advanced analytical tools particularly applying a system biology approach allow identification of selective biosynthetic pathways, which when transferred to a recombinant host provide a sustainable route to scale these compounds. Moreover, the use of marine fishing waste allows for a circular approach to generate value-adding natural products that have various applications ranging from food over chemical to pharmaceutical applications.
This Research Topic series is concerned with the entire process from discovery to sustainable production routes for value-adding natural products. A special emphasis is given to systems biology approaches to the identification of new natural product, biosynthetic pathways and the use of marine waste to generate new, sustainable products for human use. The application of whole-cell or cell-free biocatalytic cascades for generation of natural products or derivatives thereof constitutes another focal point of this Research Topic. Moreover, new or existing processes should be analysed using techno-economic and life cycle analysis tools to demonstrate their scalability and potential industrial viability. Authors are invited to submit review articles, communications and full research articles.
This Research Topic welcomes submissions focusing on the following themes:
· Marine ecology
· Identification of novel biosynthetic pathways
· Native or recombinant microbial production systems
· Biocatalytic systems
· Utilization of waste streams
· Circular bioeconomy approaches with a focus on marine systems
Marine natural products are distinct by their structural diversity and unique chemical functionalization. Most compounds discovered in marine macro-organisms are detected in minute quantities, which demands significant amounts of biomass to generate sufficient compounds for industrial application. In most cases, this practice is significantly damaging fragile marine ecosystems, such as coral reefs. Today, advanced analytical tools particularly applying a system biology approach allow identification of selective biosynthetic pathways, which when transferred to a recombinant host provide a sustainable route to scale these compounds. Moreover, the use of marine fishing waste allows for a circular approach to generate value-adding natural products that have various applications ranging from food over chemical to pharmaceutical applications.
This Research Topic series is concerned with the entire process from discovery to sustainable production routes for value-adding natural products. A special emphasis is given to systems biology approaches to the identification of new natural product, biosynthetic pathways and the use of marine waste to generate new, sustainable products for human use. The application of whole-cell or cell-free biocatalytic cascades for generation of natural products or derivatives thereof constitutes another focal point of this Research Topic. Moreover, new or existing processes should be analysed using techno-economic and life cycle analysis tools to demonstrate their scalability and potential industrial viability. Authors are invited to submit review articles, communications and full research articles.
This Research Topic welcomes submissions focusing on the following themes:
· Marine ecology
· Identification of novel biosynthetic pathways
· Native or recombinant microbial production systems
· Biocatalytic systems
· Utilization of waste streams
· Circular bioeconomy approaches with a focus on marine systems
