About this Research Topic
Extracellular vesicles (EVs) contain numerous molecules, including proteins, metabolites, mitochondrial DNA, mRNA, lipids, miRNA and other non-coding RNAs. These biomolecules act as a critical mediator in cancer initiation, progression and metastasis. EVs include species of exosomes, microvesicles (MVs), and apoptotic bodies (ABs) based on their sizes and origins.
EVs are released from different types of the eukaryotic cell to the extracellular environment after cell activation. EVs transfer varieties of bioactive molecules, such as nucleic acid, proteins, and metabolites. These cargoes participate in a variety of physiological processes, such as immunomodulation, angiogenesis, stem cell differentiation and so on. Moreover, EVs are also involved in pathological processes and are particularly implicated in many aspects of cancer development. Exploring the biology and functions of EVs in cancer is of great significance for cancer diagnostic and therapeutic. Through the bioactive molecules, the status of the cells which secreting EVs can be reflected some extent, thus reflecting the conditions of cancers.
The purpose of this Research Topic is to publish basic and translational research on the biology and function of extracellular vesicles in cancer. Nowadays, based on liquid biopsy or pathological tissue, advanced techniques have been developed to extract EVs, which are greatly advancing the process and making it possible for EVs as a clinical popular cancer biomarker in the near future. Our goal is to demonstrate the biology and functional roles of EVs in cancer, including cell proliferation, cell migration, cell invasion, cancer metastasis, immune escape, inflammatory response, drug resistance, and so on.
This Research Topic welcomes the submission of Orignal Research and Review manuscripts focused on, but not limited to, the following topics:
• Content analysis and research of Evs
• Evs functions in cancer proliferation, migration, invasion, metastasis and recurrence
• Evs functions in cancer immune regulation, inflammatory response
• Evs functions in cancer therapy, including drug resistance
• Evs functions in other aspects of cancer
Keywords: Extracellular Vesicles, Contents, Biology, pharmacological effects, Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.