Research Topic

Biology and Pharmacological Effects of Extracellular Vesicles in Cancer

About this Research Topic

Extracellular vesicles (EVs) contain numerous molecules, including proteins, metabolites, mitochondrial DNA, mRNA, lipids, miRNA and other non-coding RNAs. These biomolecules act as a critical mediator in cancer initiation, progression and metastasis. EVs include species of exosomes, microvesicles (MVs), and ...

Extracellular vesicles (EVs) contain numerous molecules, including proteins, metabolites, mitochondrial DNA, mRNA, lipids, miRNA and other non-coding RNAs. These biomolecules act as a critical mediator in cancer initiation, progression and metastasis. EVs include species of exosomes, microvesicles (MVs), and apoptotic bodies (ABs) based on their sizes and origins.
EVs are released from different types of the eukaryotic cell to the extracellular environment after cell activation. EVs transfer varieties of bioactive molecules, such as nucleic acid, proteins, and metabolites. These cargoes participate in a variety of physiological processes, such as immunomodulation, angiogenesis, stem cell differentiation and so on. Moreover, EVs are also involved in pathological processes and are particularly implicated in many aspects of cancer development. Exploring the biology and functions of EVs in cancer is of great significance for cancer diagnostic and therapeutic. Through the bioactive molecules, the status of the cells which secreting EVs can be reflected some extent, thus reflecting the conditions of cancers.

The purpose of this Research Topic is to publish basic and translational research on the biology and function of extracellular vesicles in cancer. Nowadays, based on liquid biopsy or pathological tissue, advanced techniques have been developed to extract EVs, which are greatly advancing the process and making it possible for EVs as a clinical popular cancer biomarker in the near future. Our goal is to demonstrate the biology and functional roles of EVs in cancer, including cell proliferation, cell migration, cell invasion, cancer metastasis, immune escape, inflammatory response, drug resistance, and so on.

This Research Topic welcomes the submission of Orignal Research and Review manuscripts focused on, but not limited to, the following topics:
• Content analysis and research of Evs
• Evs functions in cancer proliferation, migration, invasion, metastasis and recurrence
• Evs functions in cancer immune regulation, inflammatory response
• Evs functions in cancer therapy, including drug resistance
• Evs functions in other aspects of cancer


Keywords: Extracellular Vesicles, Contents, Biology, pharmacological effects, Cancer


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 June 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..