About this Research Topic
Liver diseases categorized into alcoholic liver disease and non-alcoholic liver diseases exhibit hepatitis and cirrhosis affected by factors majorly by age, degree of hyperammonemia, the severity of inflammation/oxidative stress, diabetes, kidney failure. The severity and complexity of the liver disease can sensitize the brain causing a great impact on brain function leading to increased risks of hepatic encephalopathy. Recent studies have shown the role of the microbiota and its role of potentially modifiable factors in liver disease progression.
This Research Topic welcomes papers analyzing the function of the gut microbiota in the gut-liver-brain axis. The areas of interest are as below:
1. The role of metabolomics, proteomics, and transcriptomics; focused on microbiome associated products.
2. Phenotypic changes of alcohol-associated injury.
3. The roles of metabolites such as secondary bile acids, endotoxin, and SCFAs.
4. Determining the role of an altered gut-brain axis in the promotion of relapse, misuse, and other disorders.
5. Nutritional changes and endotoxemia.
6. Impact of hypocaloric diets in managing disease burden.
7. Large and long-term clinical trials that adequately translate microbial findings into practice.
Keywords: Microbiome, Diet, Liver, Metabolites, SCFAs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.