A healthy gut microbiome, a diverse and dynamic microbial community assists in the digestive process, defense against foreign pathogens, and influences immune function. Malnutrition is a common but underappreciated problem and has been reported to increase with the severity of the liver disease. The impact of diet composition on the liver is bi-directional attributed by the relationship between the microbiome through multiple functions, including bile acid production and the enterohepatic circulation as well as responsiveness to gut bacterial end-products and nutrients via the portal vein.
Liver diseases categorized into alcoholic liver disease and non-alcoholic liver diseases exhibit hepatitis and cirrhosis affected by factors majorly by age, degree of hyperammonemia, the severity of inflammation/oxidative stress, diabetes, kidney failure. The severity and complexity of the liver disease can sensitize the brain causing a great impact on brain function leading to increased risks of hepatic encephalopathy. Recent studies have shown the role of the microbiota and its role of potentially modifiable factors in liver disease progression.
This Research Topic welcomes papers analyzing the function of the gut microbiota in the gut-liver-brain axis. The areas of interest are as below:
1. The role of metabolomics, proteomics, and transcriptomics; focused on microbiome associated products.
2. Phenotypic changes of alcohol-associated injury.
3. The roles of metabolites such as secondary bile acids, endotoxin, and SCFAs.
4. Determining the role of an altered gut-brain axis in the promotion of relapse, misuse, and other disorders.
5. Nutritional changes and endotoxemia.
6. Impact of hypocaloric diets in managing disease burden.
7. Large and long-term clinical trials that adequately translate microbial findings into practice.
A healthy gut microbiome, a diverse and dynamic microbial community assists in the digestive process, defense against foreign pathogens, and influences immune function. Malnutrition is a common but underappreciated problem and has been reported to increase with the severity of the liver disease. The impact of diet composition on the liver is bi-directional attributed by the relationship between the microbiome through multiple functions, including bile acid production and the enterohepatic circulation as well as responsiveness to gut bacterial end-products and nutrients via the portal vein.
Liver diseases categorized into alcoholic liver disease and non-alcoholic liver diseases exhibit hepatitis and cirrhosis affected by factors majorly by age, degree of hyperammonemia, the severity of inflammation/oxidative stress, diabetes, kidney failure. The severity and complexity of the liver disease can sensitize the brain causing a great impact on brain function leading to increased risks of hepatic encephalopathy. Recent studies have shown the role of the microbiota and its role of potentially modifiable factors in liver disease progression.
This Research Topic welcomes papers analyzing the function of the gut microbiota in the gut-liver-brain axis. The areas of interest are as below:
1. The role of metabolomics, proteomics, and transcriptomics; focused on microbiome associated products.
2. Phenotypic changes of alcohol-associated injury.
3. The roles of metabolites such as secondary bile acids, endotoxin, and SCFAs.
4. Determining the role of an altered gut-brain axis in the promotion of relapse, misuse, and other disorders.
5. Nutritional changes and endotoxemia.
6. Impact of hypocaloric diets in managing disease burden.
7. Large and long-term clinical trials that adequately translate microbial findings into practice.