Research Topic

Computational Biomechanics of the Heart and Vasculature with Potential Clinical and Surgical Applications

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About this Research Topic

Mechanical forces play an important role in cardiovascular disease initiation, development, treatment strategy and medication considerations, and remodeling and recovery processes after clinical and surgical Applications. Ventricle and vulnerable plaque are active areas where computational modeling and ...

Mechanical forces play an important role in cardiovascular disease initiation, development, treatment strategy and medication considerations, and remodeling and recovery processes after clinical and surgical Applications. Ventricle and vulnerable plaque are active areas where computational modeling and biomechanics have made remarkable advances in investigating mechanisms governing disease development and finding optimal strategies for the management and treatment of those diseases and improving public health. Multi-disciplinary collaborations from medical imaging, bioengineering, computational modeling, tissue regeneration and others may lead to advances in clinical applications. Papers in this topic will help to promote research in this area which eventually will lead to advancement of better treatment and management technology and strategies.

The Guest Editors of this Research Topic welcome original research articles or reviews which aim to:

- Advance ventricle biomechanical modeling to better understand ventricle function, disease initiation and development, ventricle remodeling, optimization of surgical treatment;
- Advance vulnerable plaque biomechanical modeling to better understand mechanisms governing plaque development and rupture, plaque remodeling, optimization of surgical treatment including stenting, graft and others.

Specific topics include, but are not limited to, the following areas:

• Ventricle biomechanical modeling to better understand ventricle function, disease initiation and development, ventricle remodeling, optimization of surgical treatment.
• Vulnerable plaque biomechanical modeling to better understand mechanisms governing plaque development, remodeling, rupture, and optimization of surgical treatment including stenting, graft and others.
• Predictive methods for surgical outcome, ventricle surgical procedure improvement, plaque progression and rupture are encouraged.
• Collaborative research integrating modeling, mechanical testing, tissue regeneration, surgical design, molecular and cellular investigations.
• Advance patient-specific image-based modeling with potential clinical applications.
• Theoretical and mathematical models of tissue growth and disease progression.
• Atheroma/aneurysm rupture prediction using AI, mathematical, computational approached.
• Experimental approaches for measurements of the cardiovascular system, including pressure, velocity, deformation, or displacement, etc.
• Biomechanical and mechanobiology of ventricular function and remodeling during physiological and pathological events.
• Multi-scale modeling of the evolving properties of cardiac mechanics in health and disease.
• Hemodynamics-based optimization of implantable and interventional medical devices for cardiovascular disease.
• Cardiovascular blood flow simulation and functional assessment of coronary stenosis.


Keywords: Ventricle Modeling, Vulnerable Plaques, Plaque Progression, Stent, Cardiovascular Disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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