About this Research Topic
The elucidation of the diversity of GPCR signal transduction in health and disease opens new possibilities in drug target design and it paces the way to improved therapies. The aim of this Research Topic is to present the state of the art in GPCR signal transduction in health and disease through the description of recent efforts at elucidating GPCR signaling pathways and their regulation, as well as through examples of their relevance in particular physio- and pathological contexts.
The Editors welcome DIFFERENT SUBMISSION TYPES (reviews, research articles, methods, perspectives/opinions, etc.) and invite contributions particularly covering the following areas:
- complexity of GPCR signal transduction: description of molecular interactions within GPCR signaling pathways and their regulation and dynamics that give rise to signal specificity
- elucidation of GPCR signaling molecules, pathways and signaling hubs relevant in different physio- and pathological contexts
- functional consequences of genetic variations, expression levels, partner availability, … in GPCRs or in their transduction/signaling partners
- investigation of GPCR signal transduction in relevant cell-based and animal disease models and translation of knowledge from heterologous expression systems
- unconventional modulation of the signal transduction of established or emerging GPCR drug targets by strategies beyond small-molecule GPCR ligands (nanobodies, pathway specific disruptors/inhibitors, genome editing, …)
This collection will be compiled in cooperation with ERNEST COST Action.
Keywords: GPCR, signal transduction, physiology, pathophysiology, signaling, G protein-coupled receptors, cellular, animal based models, drug target design
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.