Research Topic

Mechanobiology and the Microenvironment: Computational and Experimental Approaches

About this Research Topic

The microenvironment in tissues is highly complex, with diverse mechanical architectures and signals that direct cell and tissue behavior. The interplay and feedback between cells and their surrounding microenvironment result in coordinated physiological processes including cell migration and tissue morphogenesis and pathological processes such as tumor progression and tissue dysfunction. Many diverse interactions occur across multiple scales that induce and respond to microenvironment remodeling.

In vitro experimental studies help reveal underlying mechanisms including key signaling pathways and cytoskeletal and cell-cell interactions. Advances in molecular and imaging techniques help dissect spatial and temporal events, e.g. cytoskeletal dynamics and organization and subcellular profiles. The development and application of mechanically tunable substrates and physiologically mimicking 3D scaffolds help reveal the influence of mechanical and physical environmental cues on cell behavior. Co-culture systems facilitate the dissection of heterotypic cell-cell interactions. Spheroid and organoid systems probe collective behaviors and mimic tumors or small sections of functional tissue. Advances in these areas are crucial in elucidating empirical evidence of how mechanical and physical phenotypes arise in biological systems.

Computational and theoretical models help reveal physical principles that govern complex behaviors, including the emergence of collective behaviors from local interactions. Wide parameter spaces can be explored, and theoretical concepts can be derived and tested. Complex behaviors can be interpreted mathematically, providing rigorous quantitative guidelines.

In this Research Topic, we welcome Original Research or Review articles on the following recommended topics. Additional relevant topics are also acceptable.

• cytoskeletal dynamics and mechanotransduction
• cell migration and/or collective behaviors in complex microenvironments
• novel bioscaffolds and applications to help model developmental or disease processes
• theoretical or computational models examining biophysical interactions at the molecular, cellular, or tissue scales


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The microenvironment in tissues is highly complex, with diverse mechanical architectures and signals that direct cell and tissue behavior. The interplay and feedback between cells and their surrounding microenvironment result in coordinated physiological processes including cell migration and tissue morphogenesis and pathological processes such as tumor progression and tissue dysfunction. Many diverse interactions occur across multiple scales that induce and respond to microenvironment remodeling.

In vitro experimental studies help reveal underlying mechanisms including key signaling pathways and cytoskeletal and cell-cell interactions. Advances in molecular and imaging techniques help dissect spatial and temporal events, e.g. cytoskeletal dynamics and organization and subcellular profiles. The development and application of mechanically tunable substrates and physiologically mimicking 3D scaffolds help reveal the influence of mechanical and physical environmental cues on cell behavior. Co-culture systems facilitate the dissection of heterotypic cell-cell interactions. Spheroid and organoid systems probe collective behaviors and mimic tumors or small sections of functional tissue. Advances in these areas are crucial in elucidating empirical evidence of how mechanical and physical phenotypes arise in biological systems.

Computational and theoretical models help reveal physical principles that govern complex behaviors, including the emergence of collective behaviors from local interactions. Wide parameter spaces can be explored, and theoretical concepts can be derived and tested. Complex behaviors can be interpreted mathematically, providing rigorous quantitative guidelines.

In this Research Topic, we welcome Original Research or Review articles on the following recommended topics. Additional relevant topics are also acceptable.

• cytoskeletal dynamics and mechanotransduction
• cell migration and/or collective behaviors in complex microenvironments
• novel bioscaffolds and applications to help model developmental or disease processes
• theoretical or computational models examining biophysical interactions at the molecular, cellular, or tissue scales


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 April 2021 Abstract
01 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 April 2021 Abstract
01 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..