Application of antigen cross-presentation research into patient care

174.4K

views

38

authors

12

articles

Application of antigen cross-presentation research into patient care

174.4K

views

38

authors

12

articles

Editorial

17 June 2014

Application of Antigen Cross-Presentation Research into Patient Care

Thijs W. H. Flinsenberg

and

Marianne Boes

4,749 views

4 citations

Editors

1

Marianne Boes

Utrecht University

Impact

About

The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view.

Download ebook

PDF

EPUB

Share

Editors

Marianne Boes

Utrecht University

Impact

174,351 Total views

135,086 Article views

36,511 Article downloads

2,754 Topic views

Published In

Frontiers in Immunology

Antigen Presenting Cell Biology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic