About this Research Topic
Parental genetics and environmental factors affect the in-utero and postnatal growth of the offspring. Growing evidence highlights that parental conditions, including their age, dietary habits, health, behaviour and associated responses, before or during critical periods of fetal development can alter their offspring's epigenetic and molecular imprints, causing abnormal development or making them vulnerable to the diseases in their life span. A complex interaction that exists between genetic makeup and parents' environmental situation regulates the disease susceptibility of the offsprings. Establishing/understanding the potential link between the parental condition and epigenetic/molecular/biochemical changes in the offsprings ultimately promises to develop early disease biomarkers and therapeutic advancements.
Recent genetic and epigenetic studies have provided much-needed evidence to understand the influence paternal genetics and environment before (both maternal and paternal) or during the early development (maternal) of the offspring has on the future onset of diseases. This special issue aims to provide a comprehensive picture of the recent developments and future challenges in the area.
This special issue aims to collect original research or review articles on the influence of parenteral conditions on the developing embryo/offspring. Potential topics include, but are not limited to:
1. Role of parental nutrition in the development of offspring's disease
2. Studies on the interaction of parental genetics and environment in the programming of offspring's adult health
3. Integrative and bioinformatic analysis of genomic or epigenomic data advancing the area of research
4. Relevant biomarkers for assessing the offspring's health consequences
5. Clinical studies on parental contribution to offspring's health
Keywords: Development, epigenetics, fetal origin, Parental nutrition, growth
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.