Reactive oxygen species (ROS) are considered a damaging natural byproduct of cellular metabolism, which possesses various roles, such as the modulation of cell survival, cell death, differentiation, inflammation, and cell signaling. Under normal conditions, the ROS level is modulated via the role of the antioxidant enzymes. ROS are implicated in the counterbalance between stem cell self-renewal and differentiation capacities, which is essential for cellular hemostasis. On the other hand, the oxidative stress from excessive ROS generation negatively affects the proliferation, differentiation, survival, and senescence of stem cells. Taken together, the modulation of ROS signaling is crucial for stem cell function and fate.
This Research Topic aims to shed light and gather novel research on the crosslink between ROS signaling and stem cell biological functions. We welcome Original Research, Reviews and other articles types falling under the following topics:
1. To afford an overview of ROS signaling and stem cell proliferation, self-renewality, stemness, and differentiation.
2. To define novel natural or synthetic compounds with ROS modulation capacities and verification in various functions and characteristics of stem cells.
3. To characterize the effects of ROS level in stem reprogramming.
4. To seek novel techniques for determining ROS source and level during stem cell proliferation and differentiation.
5. To find out novel signaling molecules targeting ROS generation and further medical applications.
Reactive oxygen species (ROS) are considered a damaging natural byproduct of cellular metabolism, which possesses various roles, such as the modulation of cell survival, cell death, differentiation, inflammation, and cell signaling. Under normal conditions, the ROS level is modulated via the role of the antioxidant enzymes. ROS are implicated in the counterbalance between stem cell self-renewal and differentiation capacities, which is essential for cellular hemostasis. On the other hand, the oxidative stress from excessive ROS generation negatively affects the proliferation, differentiation, survival, and senescence of stem cells. Taken together, the modulation of ROS signaling is crucial for stem cell function and fate.
This Research Topic aims to shed light and gather novel research on the crosslink between ROS signaling and stem cell biological functions. We welcome Original Research, Reviews and other articles types falling under the following topics:
1. To afford an overview of ROS signaling and stem cell proliferation, self-renewality, stemness, and differentiation.
2. To define novel natural or synthetic compounds with ROS modulation capacities and verification in various functions and characteristics of stem cells.
3. To characterize the effects of ROS level in stem reprogramming.
4. To seek novel techniques for determining ROS source and level during stem cell proliferation and differentiation.
5. To find out novel signaling molecules targeting ROS generation and further medical applications.
