Malignant tumor is one of the main causes of death worldwide, and the current mono-therapy approaches, such as surgery, chemotherapy and radiotherapy have shown unsatisfactory response due to the resistance of radiotherapy and chemotherapy, a high rate of recurrence and metastasis, and severe side-effect. Cancer is usually the result of a combination of inter connected disease pathways that may not be treated effectively with a single therapeutic agent or strategy. Thus, there is a pressing need for rational and sequential combination therapies to improve therapeutic responses and prolong the survival of cancer patients. However, it remains a challenge to integrate multimodal therapies with high efficacy, specificity and personalization.
The booming development of nanomedicine provides a new platform and technique for high-efficient and safe combination therapies. The emergence of nano drug delivery system has allowed new approaches for preferentially delivering theranostic agents to the tumor tissues for improving therapeutic targeting, reducing systemic toxicity and overcoming multi-drug resistance. Furthermore, some multifunctional biomaterials have also shown the great ability to modulate the tumor microenvironment such as hypoxia, acidity and redox, due to the special properties of the material itself. Therefore, these multifunctional biomaterials have great potentials in integrating multimodal therapies for achieving optimal and synergetic combination therapies.
In this Research Topic, we will focus on the elaborate design and development of nanomaterials for the combination therapies of cancer, and also collect the researches on unique approaches for cancer treatments based on the multifunctional biomaterials. We aim to surmount the current challenges in cancer treatment and explore the novel application of biomaterials in cancer theranostics. We expect the research topics could provide new sights and promising strategies for cancer combination therapies and, advance the development and clinical application of nanomaterials.
Malignant tumor is one of the main causes of death worldwide, and the current mono-therapy approaches, such as surgery, chemotherapy and radiotherapy have shown unsatisfactory response due to the resistance of radiotherapy and chemotherapy, a high rate of recurrence and metastasis, and severe side-effect. Cancer is usually the result of a combination of inter connected disease pathways that may not be treated effectively with a single therapeutic agent or strategy. Thus, there is a pressing need for rational and sequential combination therapies to improve therapeutic responses and prolong the survival of cancer patients. However, it remains a challenge to integrate multimodal therapies with high efficacy, specificity and personalization.
The booming development of nanomedicine provides a new platform and technique for high-efficient and safe combination therapies. The emergence of nano drug delivery system has allowed new approaches for preferentially delivering theranostic agents to the tumor tissues for improving therapeutic targeting, reducing systemic toxicity and overcoming multi-drug resistance. Furthermore, some multifunctional biomaterials have also shown the great ability to modulate the tumor microenvironment such as hypoxia, acidity and redox, due to the special properties of the material itself. Therefore, these multifunctional biomaterials have great potentials in integrating multimodal therapies for achieving optimal and synergetic combination therapies.
In this Research Topic, we will focus on the elaborate design and development of nanomaterials for the combination therapies of cancer, and also collect the researches on unique approaches for cancer treatments based on the multifunctional biomaterials. We aim to surmount the current challenges in cancer treatment and explore the novel application of biomaterials in cancer theranostics. We expect the research topics could provide new sights and promising strategies for cancer combination therapies and, advance the development and clinical application of nanomaterials.
