About this Research Topic
The liver is mainly composed of hepatocytes, cholangiocytes, liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs), and Kupffer cells. These cells cooperatively regulate hepatic function in numerous physiological processes, including glucose metabolism, lipid, cholesterol homeostasis, energy balance, blood volume regulation, immune responses. However, the liver is also vulnerable to multiple pathogenic factors, such as viral hepatitis, alcoholic liver disease (ALD), metabolic associated fatty liver disease (MAFLD), autoimmune liver disease, liver cirrhosis, and hepatocellular carcinoma (HCC), and their complications. Liver diseases affect millions of people worldwide and is a substantial health burden in many countries. Although significant advances have been made in preventing liver disease, the global morbidity and mortality rate of liver diseases remains high. It is urgent to find new molecular and cellular mechanisms underlying the development of chronic liver diseases and to support the devolvement of new therapeutic targets.
The present Research Topic aims to report the most recent molecular and cellular mechanisms of chronic liver diseases. The topic will be open to review and research articles that focus on, but not limited to, the following themes:
1. Novel mechanisms of chronic liver diseases, such as viral hepatitis, alcoholic liver disease, metabolic associated fatty liver disease (MALFD) & metabolic associated steatohepatitis (NASH), Liver fibrosis/cirrhosis, autoimmune liver disease, drug-induced liver injury (DILI), hepatocellular carcinoma, and cholangiocarcinoma, etc.
2. New technology and new tools in the study of chronic liver diseases
3. Novel therapeutic targets for chronic liver diseases
4. Epigenetics of chronic liver diseases
5. Inflammation regulation in chronic liver diseases
6. The role of liver cells in the development of chronic liver diseases
Keywords: Chronic liver diseases, liver fibrosis, viral hepatitis, metabolic associated fatty liver disease, autoimmune liver disease, liver cirrhosis, hepatocellular carcinoma
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.