About this Research Topic
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Cancer is a group of diseases affecting abnormal cell growth to invade or spread to other parts of the body. The continuous inflammatory responses could result in cell mutation and proliferation and often creates an environment that is conducive to the development of cancer. Despite many advances in the therapeutic strategies against these diseases, their medical applications have been seriously restricted by problems with long-term therapeutic efficacy and unwanted adverse effects. Nanoparticles and vaccines have significant advantages, such as high antigen loading efficiency, good targeting, low toxicity, high stability, and diverse administration methods etc. As such, these novel approaches will have significant superiority in inflammation and cancer treatment.
Nanoparticle-based drug delivery systems have recently gained attention for inflammation and cancer treatment, and some achievements have been discovered in the pre-clinical study. However, for clinical translational application, numerous issues have to be addressed in the future, including: (1) the ability to yield a high local drug concentration at the disease site, which should yield prolonged pharmacological activity and maximize drug efficacy; (2) the ability to prevent or reduce the likelihood that a drug will be degraded and lose its efficacy before reaching the site of action; and (3) the potential to reduce dosing frequency and minimize systemic side effects. This Research Topic aims to highlight the advanced studies and strategies which might overcome current obstacles in the treatment of inflammation and cancer.
The following topics are interesting but not limited to:
• Small therapeutic molecules against inflammation and cancer
• Novel delivery materials for inflammation and cancer treatment
• Novel therapeutic approaches, including vaccines, for inflammation and cancer
• Novel diagnosis approaches for inflammation and cancer
Keywords: Drug delivery system, nanoparticles, Vaccine, inflammation, cancer, therapy
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