Research Topic

Biomaterials with the regulation of reactive oxygen/nitrogen species for biomedical applications

About this Research Topic

Recently, reactive oxygen/nitrogen species (RONS) have attracted tremendous research interests from the viewpoint of fundamental research and practical applications in the biomedical field. It has been well-demonstrated that RONS can induce oxidative stress and injury as well as contribute to ...

Recently, reactive oxygen/nitrogen species (RONS) have attracted tremendous research interests from the viewpoint of fundamental research and practical applications in the biomedical field. It has been well-demonstrated that RONS can induce oxidative stress and injury as well as contribute to inter-/intra-cellular signal transduction, mediating various physiological activities of organisms. On one hand, the imbalance of redox homeostasis caused by RONS is related to the development of diseases. On the other hand, the local augment of RONS can be applied for anti-bacteria/virus/cancer. Therefore, the precise regulation of RONS in organisms and their surrounding microenvironment plays a critical role in the treatment of diseases as well as tissue repair and regeneration. Particularly, functional biomaterials with rational design and preparation techniques have emerged as a new generation of RONS mediators, which have enormous potential in advanced biomedical applications.



Despite impressive advances in RONS mediated by biomaterials for biomedical applications, there are a variety of questions still pending in this research direction. For instance, how to design smart biomaterials for mediating the dynamic changes of RONS for specific biomedical purposes? How do RONS-producing biomaterials interact with bacteria/virus/cancer and their underlying mechanisms? How do functional biomaterials with unique RONS regulation properties modulate cell responses as well as promote tissue repair and regeneration? How to control the toxicity of RONS-producing biomaterials inside the body? In this Research Topic, we aim to cover recent research in functional biomaterials with unique abilities of RONS regulation for advanced biomedical applications.



We cordially welcome investigators to submit articles (original research, review, mini-review, and perspective articles). Potential topics include, but are not limited to:



• Design and preparation of functional biomaterials that respond to biological levels of RONS

• RONS-producing biomaterials for anti-bacteria/virus/cancer

• RONS-scavenging biomaterials for the treatment of diseases (e.g., wound healing, cardiovascular disease, Alzheimer's disease, inflammation, etc.)

• The underlying mechanisms and interactions between RONS-mediated biomaterials and organisms

• Toxicology studies on RONS-induced biomaterials


Keywords: reactive oxygen species, reactive nitrogen species, biomaterials, anti-bacteria, anticancer, disease treatment, tissue repair and regeneration


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

24 November 2021 Manuscript
30 June 2022 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

24 November 2021 Manuscript
30 June 2022 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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