In the area of biomedicine, important disorders such as cancer, neurodegenerative and infectious diseases are yet to be addressed using advanced material-based therapies. Moreover, the application of nanomaterials in tissue engineering and regenerative medicine has a significant impact since they can provide contrast for imaging, deliver growth factors and serve as tissue scaffolds. Furthermore, as a response to the coronavirus pandemic, nanomaterials were shown to offer an effective solution to mRNA delivery in vaccines.
After exposure to biological fluids, nanomaterials are known to strongly engage with the biomolecules including proteins and lipids from the surrounding media forming the so-called bio-corona. As the bare surface of the particle is dramatically altered, the biomolecular corona can affect the nanomaterial therapeutic efficacy as well as the immunological response in the host. Coating of the nanomaterial with biocompatible polymers, such as poly (ethylene glycol) or PEG, is a common strategy to attenuate the biomolecular corona formation and to increase the colloidal stability of nanoparticles. However, evidence has shown that this can also trigger an acute or chronic immunological response mediated by complement activation and antibody-dependent mechanisms, respectively.
While nanotechnology plays a crucial role in biomedicine, insufficient understanding of the nano-bio interactions hinders the transfer of nanomaterials into the clinic. The mechanisms at play when nano meets bio are not fully understood yet and require further investigation. Studying nano-bio interactions can aid in predicting the nanosafety response and may ultimately lead to the design of safer products for biomedical use.
The aim of this Research Topic is to attract contributions in the nano-bioscience area to highlight the latest developments in nanotechnology-based systems, with particular focus on:
-Immune responses (acute and chronic) to nanomaterials
-Nanosafety assessment of nanoparticles used in nanomedicine (including vaccines)
-Correlation of nanoparticle surfaces with complement activation-related pseudoallergy
-Biomimetic nanoparticles as immune camouflage (stealth)
-Biomolecular corona, and the journey of nanoparticle inside cells
-Transformation and fate of nanomaterials in biological systems
-Influence of polymer coating (including PEG) on bio-corona formation
-Nanoparticles in tissue engineering
-Nanoparticles to treat infectious diseases
-Nanoparticles for blood-brain barrier passage
We welcome contributions on the interactions of nanomaterials with biological entities, including both original research papers, as well as mini-reviews/perspectives and review papers.
Note: Dr. Pompa is co-founder and partner of Hiqnano Srl, has several grants from private companies, and is author of >25 patents. However, as a Guest Editor of this Special Issue, he has no conflicts of interest to declare.
In the area of biomedicine, important disorders such as cancer, neurodegenerative and infectious diseases are yet to be addressed using advanced material-based therapies. Moreover, the application of nanomaterials in tissue engineering and regenerative medicine has a significant impact since they can provide contrast for imaging, deliver growth factors and serve as tissue scaffolds. Furthermore, as a response to the coronavirus pandemic, nanomaterials were shown to offer an effective solution to mRNA delivery in vaccines.
After exposure to biological fluids, nanomaterials are known to strongly engage with the biomolecules including proteins and lipids from the surrounding media forming the so-called bio-corona. As the bare surface of the particle is dramatically altered, the biomolecular corona can affect the nanomaterial therapeutic efficacy as well as the immunological response in the host. Coating of the nanomaterial with biocompatible polymers, such as poly (ethylene glycol) or PEG, is a common strategy to attenuate the biomolecular corona formation and to increase the colloidal stability of nanoparticles. However, evidence has shown that this can also trigger an acute or chronic immunological response mediated by complement activation and antibody-dependent mechanisms, respectively.
While nanotechnology plays a crucial role in biomedicine, insufficient understanding of the nano-bio interactions hinders the transfer of nanomaterials into the clinic. The mechanisms at play when nano meets bio are not fully understood yet and require further investigation. Studying nano-bio interactions can aid in predicting the nanosafety response and may ultimately lead to the design of safer products for biomedical use.
The aim of this Research Topic is to attract contributions in the nano-bioscience area to highlight the latest developments in nanotechnology-based systems, with particular focus on:
-Immune responses (acute and chronic) to nanomaterials
-Nanosafety assessment of nanoparticles used in nanomedicine (including vaccines)
-Correlation of nanoparticle surfaces with complement activation-related pseudoallergy
-Biomimetic nanoparticles as immune camouflage (stealth)
-Biomolecular corona, and the journey of nanoparticle inside cells
-Transformation and fate of nanomaterials in biological systems
-Influence of polymer coating (including PEG) on bio-corona formation
-Nanoparticles in tissue engineering
-Nanoparticles to treat infectious diseases
-Nanoparticles for blood-brain barrier passage
We welcome contributions on the interactions of nanomaterials with biological entities, including both original research papers, as well as mini-reviews/perspectives and review papers.
Note: Dr. Pompa is co-founder and partner of Hiqnano Srl, has several grants from private companies, and is author of >25 patents. However, as a Guest Editor of this Special Issue, he has no conflicts of interest to declare.