Research Topic

Emerging SARS-COV-2 Variants: Genomic Variations, Transmission, Pathogenesis, Clinical Impact and Interventions

About this Research Topic

Since early 2021, multiple SARS-CoV-2 variants have emerged in various countries across the globe. Of these, ‘Variant of Concern’ has been reported to be highly

transmissible, infectious and escape the natural or vaccine-induced immune response. The rapid spread of these variants has led to a daily ...

Since early 2021, multiple SARS-CoV-2 variants have emerged in various countries across the globe. Of these, ‘Variant of Concern’ has been reported to be highly

transmissible, infectious and escape the natural or vaccine-induced immune response. The rapid spread of these variants has led to a daily increase in the SARS-CoV-2 cases associated with severe morbidity and mortality causing the pandemic situation worse.

With the reduced susceptibility to the currently available vaccines, the newly emerged variants have become a serious threat to the global COVID-19 vaccination program. It is important to carry out active genomic surveillance of SARS-CoV-2 variants, understand their transmission, pathogenesis and determine the efficacy of the vaccines and other therapeutics against these variants.

We hope that through this Research Topic, we can explore the global emergence and prevalence of SARS-CoV-2 variants, key mutations impacting transmission, infectivity,

pathogenicity and associated immune escape against vaccines and other therapeutics. In this Research Topic, we aim to welcome the submission of high-quality articles focusing on the investigations and research on emerging SARS-CoV-2 variants.

We welcome submissions of Original Research, Review, Mini Review, correspondence focusing on the following aspects:

Genomic surveillance of the emerging variants
Isolation and characterization of the SARS-CoV-2 variants
Transmission and pathogenesis of the newly emerged strain
Clinical consequences associated with the variants
Assessment of the efficacy of the vaccines and other therapeutics
Bioinformatic and nomenclature solutions for real time
Global viral genome data sharing and comparative analysis
Other intervention measures


Keywords: SARS-CoV-2, Variants, Genome, Transmission, Pathogenesis, Clinical impact, Interventions


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 November 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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