About this Research Topic
Cancer cachexia is seen in at least 50% of solid tumor patients, responsible for 30% of all cancer-related deaths and reduced median patient survival. There are no durable interventions for cancer cachexia, in part due to the lack of adequate mechanistic insight into the syndrome. We are confident, however, that independent of tumor-directed therapies, successful treatment of cancer cachexia would improve patient survival and quality of life.
Within this Frontiers of Oncology Research Topic focused on cancer cachexia, we aim to provide a series of articles that exposes readers to novel basic, translational, and clinical approaches that are aimed at better understanding and treating cancer cachexia. We hope to create a special issue that is accessible and interesting to a wide audience - oncologists from many primary cancer focuses, cancer biologists, nutritionists, palliativists, geriatricians, host tissue biologists (adipose, muscle, liver, CNS, immune/inflammatory systems), molecular biologists, biochemists, translationalists, clinicians, and basic science researchers.
We aim to have articles with more outside the box approaches that focus on studies of tumor and host tissues including adipose, muscle, brain, liver, etc. We aim to include basic/mechanistically-driven translational study papers and clinically-focused papers. It is anticipated that this Research Topic will also spur increased enthusiasm for the systems biology approaches necessary to understand and optimize cancer cachexia patient care.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Cancer, Cachexia, Anorexia, Tumor-Directed Therapy, Patient Care
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.