About this Research Topic
Zoonoses represent one of the major public health problems which affect the entire globe. Both wild and domestic animals are considered to be the main pathogen reservoirs. The continuous interconnections occurring between animals and humans enable the rapid adaptation of a growing number of animal pathogens to interact and infect human cells. This results in a steadily increasing number of human pathogens cataloged as being zoonotic, including emerging infectious diseases.
Tackling this phenomenon requires an interdisciplinary approach that accounts for both the human and animal sectors as well as the environmental ecosystem where these coexist. The One-Health concept involves the complementary cooperation of multiple disciplines. It relies on cutting-edge technologies (e.g., omics science) to gain a comprehensive overview of the biology and pathogenetic mechanisms of pathogens, along with the study of host response and the molecular mechanisms that enable the onset and progression of infections. A thorough understanding of these aspects facilitates the control of zoonotic infections: ranging from the development of effective therapeutic strategies to the amendment of diagnostic standards and design of effective prophylactic strategies.
This Research Topic aims to provide a comprehensive overview and to highlight the latest research on the One-Health approach in the study of infections of zoonotic relevance. Particular attention will be dedicated to the study of the molecular mechanisms which enable the onset and progression of zoonotic infections as well as the host response and the molecular events leading the pathogens to widen the spectrum of the hosts.
The scope of the Research Topic includes, but is not limited to, Original Research and Review articles addressing the following areas of research:
• Omics sciences applied to the study of pathogens of zoonotic relevance;
• Omics-based studies of the environmental survival and/or shedding of zoonotic pathogens;
• The host-pathogen interplay in the onset and/or progression of the infections;
• One-Health studies aiming at the control of zoonotic agents dissemination and infection with a focus on the transboundary infections and the emerging diseases;
• Elucidation of the molecular mechanisms employed for the host spectrum widening and the host-pathogen crosstalk.
Keywords: Animal infections, Human infections, zoonoses, One-health, transdisciplinary approach, public health, omics sciences, virus, bacteria, parasites, microbiota, microbiome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.