Improving Efficacy and Safety of drugs in pediatric population: New Challenges

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120

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articles

Improving Efficacy and Safety of drugs in pediatric population: New Challenges

106.1K

views

120

authors

18

articles

Editors

5

Domenica Altavilla

University of Messina

Annalisa Capuano

University of Campania Luigi Vanvitelli

Eloisa Gitto

University of Messina

Serafina Perrone

University of Parma

Francesco Salvo

Université de Bordeaux

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Background: The physiological characteristics of children are different from those of adults, because of immature and not yet fully developed systems. This renders the pharmacokinetics and the pharmacodynamics of drugs more complex in the pediatric population especially in newborns and those delivered preterm that are more prone to oxidative stress than individuals later in life.

Goal: The preclinical and clinical research of new drugs and vaccines for the main pediatric diseases is hampered by ethical and regulatory issues. The translational research and the identification of innovative molecular targets particular for the pediatric population are not yet fully developed. As a consequence, the “off-label” use of drugs and the tentative repositioning of orphan drugs in the clinical setting has recently increased, leading to a poor therapeutic appropriateness. Furthermore, a minority of the entire population is included in clinical studies of drug surveillance. Therefore, the systemic collection of information concerning drugs and vaccines most frequently associated with the onset of Adverse Drug Reactions (ADR) is of paramount importance. The goal is to provide a new, challenging scenario for the therapeutic needs in the pediatric population.

Scope and information for Author: This thematic issue will focus on these aspects with the aim to foster a more rationale and safe use of the drugs in the pediatric population. Papers dealing with preclinical and clinical research and reviews on the main pharmacological approaches of the main pediatric diseases will be suitable for publication.

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Editors

Domenica Altavilla

University of Messina

Annalisa Capuano

University of Campania Luigi Vanvitelli

Eloisa Gitto

University of Messina

Serafina Perrone

University of Parma

Francesco Salvo

Université de Bordeaux

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77,837 Article views

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Published In

Frontiers in Pharmacology

Obstetric and Pediatric Pharmacology

Frontiers in Pediatrics

Obstetric and Pediatric Pharmacology

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