Research Topic

Fabrication of In-Vitro 3D Human Tissue Models – From Cell Processing to Advanced Manufacturing

About this Research Topic

The two-dimensional (2D) cell cultures are commonly used for various testing and research applications such as drug testing, disease modelling, toxicity studies, fundamental biological studies, and tissue engineering applications. However, the use of such simple, conventional 2D cell culture is unable to ...

The two-dimensional (2D) cell cultures are commonly used for various testing and research applications such as drug testing, disease modelling, toxicity studies, fundamental biological studies, and tissue engineering applications. However, the use of such simple, conventional 2D cell culture is unable to adequately recapitulate the in vivo cell-cell and cell-matrix interactions found in native three-dimensional (3D) tissues and it has been reported that numerous types of cells have expressed different phenotypes and genomic profiles in 2D vs 3D cell culture. Hence, the fabrication of in-vitro 3D tissue models would bring about increased complexity that may improve the reliability and accuracy of test outcomes. Successful fabrication of in-vitro tissue models is dependent on two critical aspects – large-scale cell manufacturing (growing cells in vast quantities within a homogeneous physical and chemical environment) and advanced manufacturing platform (highly-automated fabrication of in-vitro tissue models with high throughput rates and repeatability).

Over the years, the field of toxicology testing has evolved tremendously from the use of animal models to 2D human cell cultures and finally the adaptation of in-vitro 3D human testing models. It is important that these in-vitro 3D human testing models predicts the human responses in an accurate and reliable manner. Hence, large-scale cell manufacturing and advanced manufacturing platform are necessary in ensuring the consistency of the fabricated in-vitro 3D human testing models. The goal of this Research Topic is to focus on the recent developments in cell processing techniques and advanced manufacturing approaches for fabrication of 3D in-vitro human tissue models.

The Research Topic aims to solicit manuscripts that describe the current state-of-the-arts, highlight recent developments and major accomplishments, future challenges, and directions towards fabrication of 3D in-vitro human tissue models, specifically in large-scale cell manufacturing and advanced manufacturing platform. Original Research, Reviews, Perspectives and Opinions summarizing the current state and future directions of the field are particularly welcome in this collection. This article collection thrives to inspire, inform and provide direction and guidance to researchers in the field.

• Development in cell expansion and processing
• Development of novel microcarriers
• Development of novel 3D bioprinting systems or strategies
• Development of novel bio-inks for 3D bioprinting


Keywords: Cell Expansion, Microcarriers, 3D Bioprinting, Bio-inks, In-vitro human tissue models


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 January 2022 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 January 2022 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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