About this Research Topic
Since buffering strongly limits the range of action of free Ca2+, the structure of the Ca2+ signalling domain and the topographical relationships between the sites of Ca2+ influx and the location of the Ca2+ sensors are central determinants in neuronal information processing. For example, postsynaptic dendritic spines act to compartmentalize Ca2+ depending on their geometry and expression of CaBPs, thereby influencing dendritic integration. At presynaptic sites it has been shown that tight, so called nanodomain coupling between Ca2+ channels and the sensor for vesicular transmitter release increases speed and reliability of synaptic transmission. Vice versa, the influence of an individual CaBP on information processing depends on the topographical relationships within the signaling domain. If e.g. source and sensor are very close, only buffers with rapid binding kinetics can interfere with signaling.
This Research Topic aims at collecting work dealing with the relationships between different [Ca2+]i controlling mechanisms in the structural context of synaptic sites and their functional implications for synaptic information processing. For this edited collection Original Research Paper, Methods, (Historical) Perspectives, Hypothesis and Theory, Comments, and Reviews or Mini-Reviews are welcome.
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