About this Research Topic
Bone regenerative materials are among the most clinically essential biomedical materials for treating bone defects caused by various skeletal diseases, such as trauma, infection, osteoporosis, or tumor resection. With the combination of materials science, tissue engineering technology (especially 3D printing technology), biology, and medicine, advanced bone regenerative materials are successfully prepared by bionic methods imitating the composition, structural characteristics, and biomineralization process of the natural bone itself. Similarly, bionic micropores have been recently applied in the clinical prosthesis interface fabrication through three-dimensional (3D) printing technology to achieve the integrated and interconnected structure, allowing surrounding bone tissue to grow into the micropores to form a powerful bone-implant interface. The commonalities and differences of bone osseointegration between the bioactive bone regenerative materials and bionic prosthesis interfaces are worthy of further exploration by researchers.
For pathological bone fractures, in addition to repair bone defects, local drug therapy targeting the related disease is necessary to regulate the microenvironments in the defects, which cannot be realized by conventional clinical techniques. Therefore, it is urgent to develop an alternative approach to repair pathological bone defects and treat the pathological local microenvironments simultaneously. Moreover, porosity parameters and structure design are key factors that influence bone ingrowth and mechanical characteristics by regulating cell behaviors and affecting the elastic modulus of implantations, respectively. Meanwhile, the material selection and preparation methods of bioactive bone regenerative materials and bionic prosthesis interface are also worthy of further exploration.
Original research or review articles are acceptable, and potential topics include, but are not limited to:
1. Development and characterizations of advanced bioactive materials for bone defect repair under different disease microenvironments.
2. Materials development and performance analysis for 3D printing porous prosthesis interface, including biocompatibility, pore characteristics, surface modifications, mechanical properties, and so forth.
3. Design, realization, and characterizations of bionic structures for bioactive bone regenerative materials and bionic prosthesis interfaces.
4. Microenvironment regulation for advanced interface osseointegration of joint prosthesis under the infection, osteoporosis, or tumor resection conditions.
5. Balance between porosities and mechanical changes in microporous structure design.
Keywords: Bioactive Material, Biomimetic Material Fabrication, Bionic Prosthesis Interface, Bone Regeneration, Interface Structure Design, Regenerative Medicine
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