As the largest organ of the body, the skin provides the first line of defense against external stressors. How cutaneous cells cope with these insults and finely coordinate stress responses to maintain fundamental physiological processes such as effective homeostasis, senescence, DNA repair, immunity and regeneration are key issues.
Some stress- activated signaling pathways occur at different hierarchies such as subcellular, cellular and systemic levels. They involve energy metabolism, mitochondrial functions and dynamics, inflammation, autophagy and cell death, which are impaired in many skin disorders.
Moreover, many stress injuries, through a metabolic transformation, can induce, effect, or even exacerbate the onset and/or relapse of skin cancers. As skin cells produce factors that promote tissue remodeling and recruit associated immune components, the balance between inflammation, stem cell response and wound healing may be altered in response to stress stimuli, thus impairing skin regeneration.
Interest in the reciprocal regulation of stress responses and metabolism in skin disorders has extensively grown over the last decade and increased expression of metabolic checkpoints has been progressively identified in skin physiology. Hence, therapeutic strategies targeting metabolism appear increasingly attractive for cutaneous diseases. The current Research Topic will provide a platform to communicate recent, promising, and novel research trends in signaling pathways that control and coordinate cellular stress responses implicated in skin diseases.
Reviews, original papers, commentaries, perspectives and case studies about inflammatory skin diseases, skin cancers, skin aging, stemness and skin regeneration will be welcome.
-Molecular pathways associated with stress responses in skin diseases, skin cancer, skin aging, stemness and skin regeneration;
-Metabolic screening in neoplastic and inflammatory skin diseases (amino acid/glucose/lipid metabolism, hypoxia, autophagy, mitochondrial metabolism);
-Skin cancer metabolic reprogramming and immune responses;
-Metastasis and metabolism reprogramming;
-Metabolic alterations as biomarkers for early diagnosis of skin diseases;
-Skin cancer: new therapeutic strategies to target metabolic reprogramming;
-Skin microenvironment and metabolism: innovative therapeutic targets.
As the largest organ of the body, the skin provides the first line of defense against external stressors. How cutaneous cells cope with these insults and finely coordinate stress responses to maintain fundamental physiological processes such as effective homeostasis, senescence, DNA repair, immunity and regeneration are key issues.
Some stress- activated signaling pathways occur at different hierarchies such as subcellular, cellular and systemic levels. They involve energy metabolism, mitochondrial functions and dynamics, inflammation, autophagy and cell death, which are impaired in many skin disorders.
Moreover, many stress injuries, through a metabolic transformation, can induce, effect, or even exacerbate the onset and/or relapse of skin cancers. As skin cells produce factors that promote tissue remodeling and recruit associated immune components, the balance between inflammation, stem cell response and wound healing may be altered in response to stress stimuli, thus impairing skin regeneration.
Interest in the reciprocal regulation of stress responses and metabolism in skin disorders has extensively grown over the last decade and increased expression of metabolic checkpoints has been progressively identified in skin physiology. Hence, therapeutic strategies targeting metabolism appear increasingly attractive for cutaneous diseases. The current Research Topic will provide a platform to communicate recent, promising, and novel research trends in signaling pathways that control and coordinate cellular stress responses implicated in skin diseases.
Reviews, original papers, commentaries, perspectives and case studies about inflammatory skin diseases, skin cancers, skin aging, stemness and skin regeneration will be welcome.
-Molecular pathways associated with stress responses in skin diseases, skin cancer, skin aging, stemness and skin regeneration;
-Metabolic screening in neoplastic and inflammatory skin diseases (amino acid/glucose/lipid metabolism, hypoxia, autophagy, mitochondrial metabolism);
-Skin cancer metabolic reprogramming and immune responses;
-Metastasis and metabolism reprogramming;
-Metabolic alterations as biomarkers for early diagnosis of skin diseases;
-Skin cancer: new therapeutic strategies to target metabolic reprogramming;
-Skin microenvironment and metabolism: innovative therapeutic targets.
