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Given the success of Volume I of this Research Topic, and how rapidly the subject area is evolving, we are pleased to announce the launch of Volume II: ...

Given the success of Volume I of this Research Topic, and how rapidly the subject area is evolving, we are pleased to announce the launch of Volume II: Novel Molecular Mechanisms and Innovative Therapeutic Approaches for Age-Associated Diseases.

Aging is a risk factor for various chronic diseases, composed of but not limited to neurological, cardiovascular, metabolic, and autoimmune conditions, as well as disorders and even many types of cancers. The global population of those aged over 65 or more is on the rise. Most elderly people are affected by many chronic diseases, which contribute to an increased risk of deaths. It is challenging to conduct in-depth research of the molecular mechanisms associated specifically with human age-related diseases, and how internal and external factors are regulating these processes. For these reasons, research has focused on finding innovative therapies that increase the specificity of the treatment and reduce their drawbacks. This Research Topic calls for a joint collaborative effort to address current knowledge and progresses being made in the molecular mechanisms associated with age-related diseases, and innovative pharmaceutical experiments that are being developed. We encourage and invite researchers with related experiences in age-associated diseases to contribute original research articles or review articles.

Subtopics include but are not limited to:

1. The latest progresses of the relationship between aging and human diseases.
2. The effects of transcriptional dysregulation on various age-associated human diseases.
3. High-throughput methods (transcriptome, metabolome, proteome, methylome, etc.) for examining age-related molecular signatures.
4. Novel mechanistic insights and targeted therapies for a personalized treatment against various age-related diseases.
5. New formulations or new therapeutic molecules useful for increasing anti-aging effectiveness and reducing toxicity.
6. Genes and proteins involved in aging or anti-aging as well as substances that inhibit or rejuvenate aging.

Keywords: Age-related diseases, Molecular mechanisms, Target therapy, Small molecular inhibitor, Therapeutic biotechnology, Molecular pharmacology, Functional genomics

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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