Adult skeletal muscle has a robust regenerative capacity, relying on a population of resident stem cells called satellite cells. Satellite cell fate is determined between quiescence and activation, self-renewal and differentiation in response of muscle injury to expand and repair the damaged myofibers and to replenish the stem cell pool for long-term tissue homeostasis. The complex fate determination process of satellite cell is controlled through the sophisticated, dynamic interplay between extrinsic factors constituting the muscle stem cell niche and intrinsic factors within satellite cells. Defects in the regulation of satellite cell fates can impair muscle regeneration, as observed in muscle degenerative diseases such as muscular dystrophy and sarcopenia in aging.
While the advance of molecular and cell biology and genetics has greatly extended our understanding of muscle stem cell biology in the past decades, the complex and exquisite regulation of satellite cell fate decision in various physiological and pathological contexts continues to fascinate researchers of the field. Emerging technologies including high-throughput single cell omics analysis, high-throughput chromosome conformation capture (Hi-C), high-resolution metabolomics and proteomics, etc. have provided advanced tools that enable us to better dissect the molecular and genetic circuitry of satellite cell fate and behavior. Thus, this Research Topic aims to highlight recent new developments on the molecular and genetic mechanisms of satellite cell fate determination in physiological and pathological conditions. We prospect new insights to be developed into the complex interplay between satellite cells and their niches, in terms of the orchestration of extrinsic factors such mechanical stress and nutritional availability with intrinsic signaling pathways and genetic regulatory network to control appropriated satellite cell fate decisions.
We are interested in original research articles, brief research reports, reviews, mini-reviews, commentaries, perspectives and methods that investigate the roles of various molecules, signaling cascades and genetic regulations in satellite cell quiescence, activation, proliferation, self-renewal and differentiation. Area to be covered in this Research Topic may include, but are not limited to:
·Identification and characterization of molecules in control of satellite cell fate and function
·Niche control of satellite cell maintenance, self-renewal, proliferation, differentiation, and aging
·Genetic and epigenetic regulation of satellite cell maintenance, self-renewal, proliferation, differentiation, and aging
·Nutritional and metabolic regulation of satellite cell maintenance, self-renewal, proliferation, differentiation, and aging
·Therapeutic targeting of satellite cells for muscle disorders
Adult skeletal muscle has a robust regenerative capacity, relying on a population of resident stem cells called satellite cells. Satellite cell fate is determined between quiescence and activation, self-renewal and differentiation in response of muscle injury to expand and repair the damaged myofibers and to replenish the stem cell pool for long-term tissue homeostasis. The complex fate determination process of satellite cell is controlled through the sophisticated, dynamic interplay between extrinsic factors constituting the muscle stem cell niche and intrinsic factors within satellite cells. Defects in the regulation of satellite cell fates can impair muscle regeneration, as observed in muscle degenerative diseases such as muscular dystrophy and sarcopenia in aging.
While the advance of molecular and cell biology and genetics has greatly extended our understanding of muscle stem cell biology in the past decades, the complex and exquisite regulation of satellite cell fate decision in various physiological and pathological contexts continues to fascinate researchers of the field. Emerging technologies including high-throughput single cell omics analysis, high-throughput chromosome conformation capture (Hi-C), high-resolution metabolomics and proteomics, etc. have provided advanced tools that enable us to better dissect the molecular and genetic circuitry of satellite cell fate and behavior. Thus, this Research Topic aims to highlight recent new developments on the molecular and genetic mechanisms of satellite cell fate determination in physiological and pathological conditions. We prospect new insights to be developed into the complex interplay between satellite cells and their niches, in terms of the orchestration of extrinsic factors such mechanical stress and nutritional availability with intrinsic signaling pathways and genetic regulatory network to control appropriated satellite cell fate decisions.
We are interested in original research articles, brief research reports, reviews, mini-reviews, commentaries, perspectives and methods that investigate the roles of various molecules, signaling cascades and genetic regulations in satellite cell quiescence, activation, proliferation, self-renewal and differentiation. Area to be covered in this Research Topic may include, but are not limited to:
·Identification and characterization of molecules in control of satellite cell fate and function
·Niche control of satellite cell maintenance, self-renewal, proliferation, differentiation, and aging
·Genetic and epigenetic regulation of satellite cell maintenance, self-renewal, proliferation, differentiation, and aging
·Nutritional and metabolic regulation of satellite cell maintenance, self-renewal, proliferation, differentiation, and aging
·Therapeutic targeting of satellite cells for muscle disorders
