Stress and Steroid regulation of synaptic transmission: from physiology to pathophysiology

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Editorial

17 January 2013

Stress and steroid regulation of synaptic transmission: from physiology to pathophysiology

Nicola Maggio

,

Harmen J. Krugers

and

Menahem Segal

4,609 views

6 citations

Editors

3

Weizmann Institute of Science

Harmen J Krugers

University of Amsterdam

Sheba Medical Center

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Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process.
In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process.
In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

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Editors

Weizmann Institute of Science

Harmen J Krugers

University of Amsterdam

Sheba Medical Center

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97,484 Total views

71,590 Article views

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Frontiers in Cellular Neuroscience

Cellular Neuroscience Archive, Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

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