Stress and Steroid regulation of synaptic transmission: from physiology to pathophysiology

97.9K

views

24

authors

11

articles

Editorial

17 January 2013

Stress and steroid regulation of synaptic transmission: from physiology to pathophysiology

Nicola Maggio

,

Harmen J. Krugers

and

Menahem Segal

4,609 views

6 citations

Editors

3

Weizmann Institute of Science

Harmen J Krugers

University of Amsterdam

Sheba Medical Center

Impact

About

Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process.
In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process.
In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

Download ebook

Share

Editors

Weizmann Institute of Science

Harmen J Krugers

University of Amsterdam

Sheba Medical Center

Impact

97,904 Total views

71,958 Article views

23,375 Article downloads

2,571 Topic views

Published In

Journal Thumbnail

Frontiers in Cellular Neuroscience

Cellular Neuroscience Archive, Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic