Biologically based tooth formation and replacement are remarkably well choreographed processes, with changes in processes and functions evolutionarily and between species. In humans existing data suggest that tooth eruption patterns and tooth morphology, both primary and secondary dentition (temporal/spatial/appearance-gross, radiographic, microCT), can be used to inform strategies to aid in diagnosis of a variety of diseases/pathologies (including environmental and drug induced)/disorders (genetic and epigenetic such as mineralized tissue disorders; nutritional disorders; hormonal disorders) and in evaluation of current health status, as well as in prediction of future health. Evidence based research in this area is invaluable for developing programs targeted at improving the health of all communities. Moreover, understanding the diversity in tooth development, tooth replacement evolutionarily and between species is important in considering therapies to diagnose and treat pathologies of the teeth, in humans and other species.
We welcome manuscripts that expand our knowledge of natural tooth replacement in humans and other species. Of interest are submissions that address the following questions but recognize there are many more vital questions:
1. What can eruption pattern/timing/mineral quality, etc. of deciduous and permanent and between species inform us about general health?
2. There are well recognized anomalies during eruption that inform health status-but are we missing more subtle variances?
3. Eruption pattern seems to have a genetic link but is it known whether eruption patterns are linked to other diseases-variants on the same chromosome? E.g., mineral tissue related disorders, autoimmune diseases?
4. What are the molecular and cellular mechanisms by which obesity, age of parents, alcohol, drugs, diet-nutrition, breast feeding, microbiome, immunological profile, genetic diseases, environmental-water, toxins, air pollution, affect tooth development in humans and other species?
5. Do we have sufficient data to steer recognized alterations in tooth development to improve formation of secondary teeth and further use biology to replace teeth lost to disease vs use of restorative materials (such as implants, dentures, crowns bridges)?
6. Can studies of tooth replacement in non-mammalian species provide clues to help the understanding of human tooth replacement?
We welcome contributions in the form of original research, reviews, case report, and perspective that cover, but not limited to, the following themes:
1. New strategies for confirming, proving, and identifying genes/proteins modulating tooth formation, to include timed resorption, exfoliation, and formation of teeth
2. Signaling pathways and associated stem cells modulating tooth formation, number of succession teeth (replacement) in time and space (all species)
3. Methods and results using organs, tissues, cells to investigate modulators of tooth formation/resorption that long term could be used for diagnosing and treating diseases
4. Animal models to inform clinical strategies to improve clinical outcomes e.g., second chance, correct a pathology identified in primary dentition
5. Discussion on the role of nutrition, diet, and environment in modulating physiological tooth development and replacement
6. The role tooth development and replacement, in health and disease, in informing the status of health/pathologies/diseases throughout the body
Biologically based tooth formation and replacement are remarkably well choreographed processes, with changes in processes and functions evolutionarily and between species. In humans existing data suggest that tooth eruption patterns and tooth morphology, both primary and secondary dentition (temporal/spatial/appearance-gross, radiographic, microCT), can be used to inform strategies to aid in diagnosis of a variety of diseases/pathologies (including environmental and drug induced)/disorders (genetic and epigenetic such as mineralized tissue disorders; nutritional disorders; hormonal disorders) and in evaluation of current health status, as well as in prediction of future health. Evidence based research in this area is invaluable for developing programs targeted at improving the health of all communities. Moreover, understanding the diversity in tooth development, tooth replacement evolutionarily and between species is important in considering therapies to diagnose and treat pathologies of the teeth, in humans and other species.
We welcome manuscripts that expand our knowledge of natural tooth replacement in humans and other species. Of interest are submissions that address the following questions but recognize there are many more vital questions:
1. What can eruption pattern/timing/mineral quality, etc. of deciduous and permanent and between species inform us about general health?
2. There are well recognized anomalies during eruption that inform health status-but are we missing more subtle variances?
3. Eruption pattern seems to have a genetic link but is it known whether eruption patterns are linked to other diseases-variants on the same chromosome? E.g., mineral tissue related disorders, autoimmune diseases?
4. What are the molecular and cellular mechanisms by which obesity, age of parents, alcohol, drugs, diet-nutrition, breast feeding, microbiome, immunological profile, genetic diseases, environmental-water, toxins, air pollution, affect tooth development in humans and other species?
5. Do we have sufficient data to steer recognized alterations in tooth development to improve formation of secondary teeth and further use biology to replace teeth lost to disease vs use of restorative materials (such as implants, dentures, crowns bridges)?
6. Can studies of tooth replacement in non-mammalian species provide clues to help the understanding of human tooth replacement?
We welcome contributions in the form of original research, reviews, case report, and perspective that cover, but not limited to, the following themes:
1. New strategies for confirming, proving, and identifying genes/proteins modulating tooth formation, to include timed resorption, exfoliation, and formation of teeth
2. Signaling pathways and associated stem cells modulating tooth formation, number of succession teeth (replacement) in time and space (all species)
3. Methods and results using organs, tissues, cells to investigate modulators of tooth formation/resorption that long term could be used for diagnosing and treating diseases
4. Animal models to inform clinical strategies to improve clinical outcomes e.g., second chance, correct a pathology identified in primary dentition
5. Discussion on the role of nutrition, diet, and environment in modulating physiological tooth development and replacement
6. The role tooth development and replacement, in health and disease, in informing the status of health/pathologies/diseases throughout the body
