Microbiota exerts pleiotropic roles in human health and disease ranging from digestion and absorption of nutrients, defense against infection, to the regulation of immune system development and immune homeostasis. Apart from the direct contact of microbes at the mucosal barrier, one of the mechanisms by which microbes can benefit human health and prevent disease is through their production of a variety of metabolites, albeit that can be a double-edged sword for the host. Although there were many studies indicating the correlation between the gut microbiome, metabolites, and immune reaction, there is a huge lack of detailed information about triangle crosstalk between them.
The question is how to identify the key intestinal bacteria or metabolites, how to illustrate the crosstalk between microbiome, metabolites, and host immune reaction, and how to take advantage of this triangle crosstalk in the future studies or clinical diagnosis or treatment.
We welcome original research articles, reviews, and commentaries on ethical, legal, and social implications of
1. The findings on newly identified bacteria playing important role in triggering autoimmune reaction.
2. The omic studies and bioinformatic analyses illustrate the network relationship between bacteria and metabolites.
3. Microbiota and metabolite kinetics studies during immune system development or immune reaction.
4. Clinic studies regarding microbiota and metabolism in autoimmune diseases.
5. The effects of metabolites on innate or adaptive immune cells activation.
6. The therapeutic potential in metabolites on autoimmune diseases.
Microbiota exerts pleiotropic roles in human health and disease ranging from digestion and absorption of nutrients, defense against infection, to the regulation of immune system development and immune homeostasis. Apart from the direct contact of microbes at the mucosal barrier, one of the mechanisms by which microbes can benefit human health and prevent disease is through their production of a variety of metabolites, albeit that can be a double-edged sword for the host. Although there were many studies indicating the correlation between the gut microbiome, metabolites, and immune reaction, there is a huge lack of detailed information about triangle crosstalk between them.
The question is how to identify the key intestinal bacteria or metabolites, how to illustrate the crosstalk between microbiome, metabolites, and host immune reaction, and how to take advantage of this triangle crosstalk in the future studies or clinical diagnosis or treatment.
We welcome original research articles, reviews, and commentaries on ethical, legal, and social implications of
1. The findings on newly identified bacteria playing important role in triggering autoimmune reaction.
2. The omic studies and bioinformatic analyses illustrate the network relationship between bacteria and metabolites.
3. Microbiota and metabolite kinetics studies during immune system development or immune reaction.
4. Clinic studies regarding microbiota and metabolism in autoimmune diseases.
5. The effects of metabolites on innate or adaptive immune cells activation.
6. The therapeutic potential in metabolites on autoimmune diseases.
