Since the establishment of the first mouse Embryonic Stem Cells (ESCs) in the 1980s, various types of ESCs in naive, formative, and primed states have been successively established. The characteristics of these various pluripotent stem cells and their long-term maintenance in vitro are of great significance to the research on early mammalian embryonic development and the clinical application of stem cells.
The goal of this Research Topic is to identify key genetic/epigenetic factors in regulating various pluripotent states in ESCs by combination of molecular/cellular assays, single cell analysis, high-content screening, and other advanced methods.
We welcome contributions in the form of articles reporting results of primary research as well as literature reviews. The topics mainly include:
- Genetic factors in regulating transitions among different pluripotent states
- Epigenetic regulation (histone modifications, non-coding RNAs and others) in pluripotent states.
- Single cell analysis in ESC fate decision.
- Signaling pathways in controlling diverse pluripotent states.
Since the establishment of the first mouse Embryonic Stem Cells (ESCs) in the 1980s, various types of ESCs in naive, formative, and primed states have been successively established. The characteristics of these various pluripotent stem cells and their long-term maintenance in vitro are of great significance to the research on early mammalian embryonic development and the clinical application of stem cells.
The goal of this Research Topic is to identify key genetic/epigenetic factors in regulating various pluripotent states in ESCs by combination of molecular/cellular assays, single cell analysis, high-content screening, and other advanced methods.
We welcome contributions in the form of articles reporting results of primary research as well as literature reviews. The topics mainly include:
- Genetic factors in regulating transitions among different pluripotent states
- Epigenetic regulation (histone modifications, non-coding RNAs and others) in pluripotent states.
- Single cell analysis in ESC fate decision.
- Signaling pathways in controlling diverse pluripotent states.
