Polyunsaturated fatty acids (PUFAs), such as linoleic acid (LA, 18:2?-6), a-linolenic acid (ALA, 18:3?-3), dihomo-?-linolenic acid (DGLA, 20:3?-6), arachidonic acid (ARA, 20:4?-6), eicosapentaenoic acid (EPA, 20:5?-3), and docosahexaenoic acid (DHA, 22:6?-3), are efficient alternative substrates of three major metabolizing enzymes: cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes. Metabolism of these PUFAS by such enzymes leads to the formation of a large array of lipid mediators (e.g., eicosanoids), which have been correlated with a variety of human disorders including inflammatory bowel disease and colorectal cancer. It is therefore critical to understand the functional role of fatty acids and fatty acid-produced metabolites on gut health, and to explore how fatty acid-microbiota interactions may play a role in gut health and function.
This Research Topic aims to bring together the results of fundamental and applied research into fatty acids and fatty acid-produced metabolites on gut health. This will help contribute to filling the gap in knowledge about the potential roles and underlying mechanisms of fatty-acids in gut health and exploring fatty acid-gut microbiota interactions in developing gut health or gut disorders.
We welcome articles including but not limited to the following themes:
• The role of lipids on gut health or gut disorders such as inflammatory bowel disease and colorectal cancer using in vivo or in vitro study;
• Metabolites of fatty acids in the gastrointestinal tract and the role of fatty acid-produced metabolites on gut disorders such as inflammatory bowel disease and colorectal cancer;
• The role of fatty acid/fatty acid-produced metabolites-gut microbiota interactions on gut disorders such as inflammatory bowel disease and colorectal cancer.
This Research Topic aims to collect publications relevant to human nutrition only. Studies on farm animals other than animal models for human nutrition will not be accepted in this Research Topic and will be re-directed to other relevant Frontiers journals.
Polyunsaturated fatty acids (PUFAs), such as linoleic acid (LA, 18:2?-6), a-linolenic acid (ALA, 18:3?-3), dihomo-?-linolenic acid (DGLA, 20:3?-6), arachidonic acid (ARA, 20:4?-6), eicosapentaenoic acid (EPA, 20:5?-3), and docosahexaenoic acid (DHA, 22:6?-3), are efficient alternative substrates of three major metabolizing enzymes: cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes. Metabolism of these PUFAS by such enzymes leads to the formation of a large array of lipid mediators (e.g., eicosanoids), which have been correlated with a variety of human disorders including inflammatory bowel disease and colorectal cancer. It is therefore critical to understand the functional role of fatty acids and fatty acid-produced metabolites on gut health, and to explore how fatty acid-microbiota interactions may play a role in gut health and function.
This Research Topic aims to bring together the results of fundamental and applied research into fatty acids and fatty acid-produced metabolites on gut health. This will help contribute to filling the gap in knowledge about the potential roles and underlying mechanisms of fatty-acids in gut health and exploring fatty acid-gut microbiota interactions in developing gut health or gut disorders.
We welcome articles including but not limited to the following themes:
• The role of lipids on gut health or gut disorders such as inflammatory bowel disease and colorectal cancer using in vivo or in vitro study;
• Metabolites of fatty acids in the gastrointestinal tract and the role of fatty acid-produced metabolites on gut disorders such as inflammatory bowel disease and colorectal cancer;
• The role of fatty acid/fatty acid-produced metabolites-gut microbiota interactions on gut disorders such as inflammatory bowel disease and colorectal cancer.
This Research Topic aims to collect publications relevant to human nutrition only. Studies on farm animals other than animal models for human nutrition will not be accepted in this Research Topic and will be re-directed to other relevant Frontiers journals.
