Starting at birth, we are exposed to various microbes, foods and other materials leading to the development and maturation of the immune system as well as the establishment of a symbiotic microbiota. All of these ‘environmental components’ heavily affect health and disease in the mammalian host. Especially in the intestine, the interplay between environmental components and host immunity modulates mucosal barrier functions as well as cytokine/chemokine production from various intestinal cells. However, it still remains to be elucidated how these environmental components mechanistically maintain homeostasis in the intestine.
The goals of this research topic are to present the highlights of the work implemented by investigators focusing on numerous environmental components, gut microbiome, mucosal barriers and immunity. Here, environmental components broadly include microbiome, food ingredients, metabolome, pollutants and chemicals, in wildlife or urban life, and at all life stages.
We are particularly interested in three aspects:
i) How environmental components modulate the gut microbiome
ii) How environmental components regulate mucosal barriers
iii) How environmental components control cytokines and chemokines production in a local milieu.
We welcome Original Research Articles, Reviews, Mini Reviews, Case Reports and Perspective articles, on any of the topics below:
- Overview on the interaction between host immunity and environmental components
- Influence of microbiome on mucosal barrier function and cytokine/chemokine production
- Modulation of intestinal homeostasis mediated by environmental components
- Influence of environmental components on development/pathogenesis of diseases
- Intervention to avoid adverse environmental impact on health and diseases.
Starting at birth, we are exposed to various microbes, foods and other materials leading to the development and maturation of the immune system as well as the establishment of a symbiotic microbiota. All of these ‘environmental components’ heavily affect health and disease in the mammalian host. Especially in the intestine, the interplay between environmental components and host immunity modulates mucosal barrier functions as well as cytokine/chemokine production from various intestinal cells. However, it still remains to be elucidated how these environmental components mechanistically maintain homeostasis in the intestine.
The goals of this research topic are to present the highlights of the work implemented by investigators focusing on numerous environmental components, gut microbiome, mucosal barriers and immunity. Here, environmental components broadly include microbiome, food ingredients, metabolome, pollutants and chemicals, in wildlife or urban life, and at all life stages.
We are particularly interested in three aspects:
i) How environmental components modulate the gut microbiome
ii) How environmental components regulate mucosal barriers
iii) How environmental components control cytokines and chemokines production in a local milieu.
We welcome Original Research Articles, Reviews, Mini Reviews, Case Reports and Perspective articles, on any of the topics below:
- Overview on the interaction between host immunity and environmental components
- Influence of microbiome on mucosal barrier function and cytokine/chemokine production
- Modulation of intestinal homeostasis mediated by environmental components
- Influence of environmental components on development/pathogenesis of diseases
- Intervention to avoid adverse environmental impact on health and diseases.