Starting at the perinatal period, we encounter a multitude of antigens, foods, pre- and probiotics, and other external factors that shape the development and maturation of the immune system, all while establishing a mutualistic relationship with our microbiota. These environmental components, collectively termed the “exposome,” significantly affect health and disease throughout our lifespan. Especially in the intestine, the interplay between exposome and host immunity regulates epithelial barrier functions as well as cytokine/chemokine production from various immune and non-immune cells. In this rapidly evolving field, new mechanisms by which the exposome maintains intestinal homeostasis are constantly being discovered. In this issue, we highlight the research that provides novel insight into host-microbiota dynamics.
In their review, Gou et al. summarized how probiotics can aid in restoring the intestinal barrier to prevent the entry of harmful substances such as pathogens and endotoxins. They highlight the effects of probiotics on tight junctions as one important mechanism for maintaining homeostasis. The majority of studies have used the cultured cell lines such as Caco-2, IPEC-1, and T84 to demonstrate how probiotics induce the expression of tight junction proteins like ZO-1, claudins, and occludins. Some studies have indicated that probiotics might promote the proliferation of intestinal epithelial cells. Another important mechanism is the modification of mucin barriers by probiotics, including the induction of MUC2 expression by L. acidophilus A4 and its cell extracts. Additionally, other studies have highlighted probiotic-mediated regulation of immune cells. For example, Lactobacillus and B. infantis can promote the maturation of dendritic cells. Further, probiotics can compete with pathogens for nutrients, competitively inhibit the attachment sites of targeted cells, or impede the spread of micro-colonies to resist the invasion of pathogens.
Tanaka et al. investigated how the host immune system recognizes and responds to adherent-invasive E. coli (AIEC), a pathobiont associated with Crohn's disease. Persistent colonization by AIEC LF82 triggered the secretion of luminal IgA, in contrast to commensal E. coli strains. The induced anti-LF82 IgA exhibited specific binding to AIEC strains but not to the commensal E. coli strains. Notably, LF82-specific IgA limited the adhesion and invasion of LF82 in cultured epithelial cells. In summary, the authors revealed that host immunity selectively recognizes pathobiont E. coli, such as AIEC, and develops specific IgA, thereby preventing these pathobionts from accessing the epithelium.
Wang et al. examined the impact of A. muciniphila-mediated post-antibiotic reconstitution of the gut microbiota on a murine model of colitis-associated colorectal cancer (CAC). The results showed that post-antibiotic replenishment of A. muciniphila exacerbated CAC tumorigenesis with impaired intestinal barrier function and elevated concentrations of short-chain fatty acids. Despite A. muciniphila being recognized for its anti-inflammatory properties, these findings provide an unexpected result. The authors suggest that maintaining the homeostasis of the intestinal microbiota may be more important than replenishing a single microbe.
In the context of the gut ecosystem, it is crucial to understand the interplay between the exposome (such as pathogens, commensals, and dietary additives) and its impact on host immunity and the cytokine milieu. The studies highlighted here provide key new insights into this dynamic. Given the additional complexity of the environmental ecosystem, future studies investigating the effects of components like pollutants/chemicals (e.g., nano and microplastics) on host immunity and the microbiome are likely to provide additional insights.
Statements
Author contributions
AH: Writing—original draft, Writing—review & editing. HA: Writing—review & editing. YI: Writing—review & editing. TD: Writing—review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
microbiome, mucosal barrier, cytokine, health, probiotics, AIEC, colitis associated cancer
Citation
Harusato A, Abo H, Itoh Y and Denning TL (2024) Editorial: Impact of gut ecosystem in health and diseases: microbiome, mucosal barrier and cytokine milieu. Front. Microbiol. 14:1345703. doi: 10.3389/fmicb.2023.1345703
Received
28 November 2023
Accepted
11 December 2023
Published
05 January 2024
Volume
14 - 2023
Edited and reviewed by
Zhiyong Li, Shanghai Jiao Tong University, China
Updates
Copyright
© 2024 Harusato, Abo, Itoh and Denning.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Akihito Harusato harup@koto.kpu-m.ac.jp
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.