Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous syndrome characterized by heart failure (HF) signs and symptoms in a setting of normal left ventricle ejection fraction. The presence of comorbidities is a peculiar characterization of HFpEF, leading to a significant increase in mortality and morbidity and favoring re-hospitalization for worsening HF. Cardiac comorbidities (including hypertension, coronary artery disease, and atrial fibrillation) and non-cardiac comorbidities (including pulmonary disease, neurological dysfunctions, sleep-disordered breathing, diabetes mellitus, anemia, renal disease, and obesity) mainly characterize a patient's phenotype, whose identification plays a pivotal role in the more appropriate therapeutic approach of the disease. Gender and age are also demographic important factors deserving attention in this syndrome.
The primary aim of this Research Topic is to create a collection of articles highlighting the importance of comorbidities driving the decision therapy algorithm in HFpEF. We would like to analyze this syndrome in both acute and chronic settings of the disease, focusing on the burden of concomitant cardiovascular or non-cardiovascular diseases, and describing gender differences and the impact of age in its management.
In this Research Topic, we invite all authors to contribute original research articles, case reports, letters to Editors, as well as review articles that address and stress the role of comorbidities. Not only cardiologists but also internal medicine specialists, neurologists, diabetologists, endocrinologists, nephrologists, and geriatricians are welcome to submit their work.
Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous syndrome characterized by heart failure (HF) signs and symptoms in a setting of normal left ventricle ejection fraction. The presence of comorbidities is a peculiar characterization of HFpEF, leading to a significant increase in mortality and morbidity and favoring re-hospitalization for worsening HF. Cardiac comorbidities (including hypertension, coronary artery disease, and atrial fibrillation) and non-cardiac comorbidities (including pulmonary disease, neurological dysfunctions, sleep-disordered breathing, diabetes mellitus, anemia, renal disease, and obesity) mainly characterize a patient's phenotype, whose identification plays a pivotal role in the more appropriate therapeutic approach of the disease. Gender and age are also demographic important factors deserving attention in this syndrome.
The primary aim of this Research Topic is to create a collection of articles highlighting the importance of comorbidities driving the decision therapy algorithm in HFpEF. We would like to analyze this syndrome in both acute and chronic settings of the disease, focusing on the burden of concomitant cardiovascular or non-cardiovascular diseases, and describing gender differences and the impact of age in its management.
In this Research Topic, we invite all authors to contribute original research articles, case reports, letters to Editors, as well as review articles that address and stress the role of comorbidities. Not only cardiologists but also internal medicine specialists, neurologists, diabetologists, endocrinologists, nephrologists, and geriatricians are welcome to submit their work.