This Research Topic will honor Prof. M. Iqbal Choudhary for his pioneering contribution in the field of Bioorganic, Synthetic, and Natural Product Chemistry. Prof. M. Iqbal Choudhary is Director and Professor of Bioorganic and Natural Product Chemistry at the International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), Pakistan and Coordinator General COMSTECH. Since 1990, Prof. Choudhary has been among the world leaders in the field of natural product chemistry, and has made pioneering contributions in the discovery of novel natural products. Prof. Choudhary has 1,212 publications (cumulative impact of > 2500) with 33,550 citations (h index 76) in the fields of organic and bioorganic chemistry. He also published 94 patents (64 US Patents), 90 books and 40 chapters in books, published by major U.S. and European presses. He discovered many potent anti-epileptic and anti-leishmanial compounds from indigenous medicinal plants that are under clinical trials. His contributions to reverse bacterial resistance to antibiotics represent seminal contributions in this important field. He has trained hundreds of young researchers, especially women, from across the Afro-Asian region in natural product chemistry and established several research centers in Pakistan, and helped to setup research units in Africa, and South and Central Asia. His scientific contributions have been recognized by prestigious national and international awards and honors, and fellowships of several academies of science.
Nature has always been a notable source of lead compounds and provided unprecedented opportunities for medicinal chemists in order to continuously provide the drug candidates. Natural products (NPs) and their derivatives have historically made a major contribution to pharmacotherapy, in particular for cancer and infectious diseases. NPs are characterized by fascinating scaffold diversity together with structural complexity and due to this NPs have long been the key source of new drugs for the treatment of numerous human diseases.
This Research Topic welcomes original articles, communications and reviews dealing with the isolation and/or the investigation of mechanisms of action of natural products and pseudo natural products (synthetic analogs of natural products) for the treatment of cancer, diabetes, infectious diseases, microbial diseases, cardiovascular diseases and other human diseases. In addition, this Research Topic also welcomes articles about the target-identification of natural products (with biological assays together with computational studies), in vivo studies and the design of novel natural product derivatives with improved biological effects.
Important Note: Frontiers in Experimental Pharmacology and Drug Discovery does not accept for publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable. This applies also to reviews, perspective, opinion. This applies also to in silico studies on supposed mechanisms underlying supposed actions of crude extracts and/or mixtures.
Whenever a complex mixture is used, data with the single components of the mixture, in precisely defined dose/concentration, should be provided (and/or previously published).
Submissions containing in vitro only data will not be considered acceptable.
This Research Topic will honor Prof. M. Iqbal Choudhary for his pioneering contribution in the field of Bioorganic, Synthetic, and Natural Product Chemistry. Prof. M. Iqbal Choudhary is Director and Professor of Bioorganic and Natural Product Chemistry at the International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), Pakistan and Coordinator General COMSTECH. Since 1990, Prof. Choudhary has been among the world leaders in the field of natural product chemistry, and has made pioneering contributions in the discovery of novel natural products. Prof. Choudhary has 1,212 publications (cumulative impact of > 2500) with 33,550 citations (h index 76) in the fields of organic and bioorganic chemistry. He also published 94 patents (64 US Patents), 90 books and 40 chapters in books, published by major U.S. and European presses. He discovered many potent anti-epileptic and anti-leishmanial compounds from indigenous medicinal plants that are under clinical trials. His contributions to reverse bacterial resistance to antibiotics represent seminal contributions in this important field. He has trained hundreds of young researchers, especially women, from across the Afro-Asian region in natural product chemistry and established several research centers in Pakistan, and helped to setup research units in Africa, and South and Central Asia. His scientific contributions have been recognized by prestigious national and international awards and honors, and fellowships of several academies of science.
Nature has always been a notable source of lead compounds and provided unprecedented opportunities for medicinal chemists in order to continuously provide the drug candidates. Natural products (NPs) and their derivatives have historically made a major contribution to pharmacotherapy, in particular for cancer and infectious diseases. NPs are characterized by fascinating scaffold diversity together with structural complexity and due to this NPs have long been the key source of new drugs for the treatment of numerous human diseases.
This Research Topic welcomes original articles, communications and reviews dealing with the isolation and/or the investigation of mechanisms of action of natural products and pseudo natural products (synthetic analogs of natural products) for the treatment of cancer, diabetes, infectious diseases, microbial diseases, cardiovascular diseases and other human diseases. In addition, this Research Topic also welcomes articles about the target-identification of natural products (with biological assays together with computational studies), in vivo studies and the design of novel natural product derivatives with improved biological effects.
Important Note: Frontiers in Experimental Pharmacology and Drug Discovery does not accept for publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable. This applies also to reviews, perspective, opinion. This applies also to in silico studies on supposed mechanisms underlying supposed actions of crude extracts and/or mixtures.
Whenever a complex mixture is used, data with the single components of the mixture, in precisely defined dose/concentration, should be provided (and/or previously published).
Submissions containing in vitro only data will not be considered acceptable.