Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology

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37

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5

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Editors

3

Rohit Ramchandra

The University of Auckland

Aisah Aubdool

Queen Mary University of London

Karie Scrogin

Loyola University Chicago

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Background
Numerous model organisms and experimental models have been developed for use in biomedical research. Their continued development and refinement have contributed to substantial scientific advances. This is particularly true in fields of study relevant to integrative physiology in which a systems approach has been used successfully to identify etiology, novel treatment targets and treatment safety concerns in diseases affecting complex living systems including humans.

Goals
Animal models of disease are designed to replicate aspects of the pathophysiology under investigation. However, most never fully reproduce the exact clinical phenotype. The resources made available under this topic are designed to highlight the challenges and limitations that accompany the creation of models and their application. This collection covers, but is not limited to, model organisms and experimental models that are used to explore the following diseases, syndromes and pathologies:

- Organoids as model systems to explore organ function
- Models to investigate neural control of the circulation
- Animal models of heart failure with preserved ejection fraction
- Animal models of hypertension – which one to use and when.
- Animal models of kidney dysfunction
- Multiple-hit animal models to replicate cardiometabolic disease
- Animal models of stroke
- Animal models of hemorrhage
- Animal models of coronary artery disease

Information for Authors
This Research Topic will seek to publish both original research and reviews related to the generation of model organisms and experimental models of disease. A better understanding of the advantages and limitations of experimental models will help guide future studies by both clinicians and basic scientists.
Manuscripts submitted to this Research Topic should be in line with the scope of the Integrative Physiology section. Several article types will be considered, please find more information here.

This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:
• Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges
• In Vitro Models: Opportunities and Challenges in Aquatic Physiology
• Animal Models and Transgenic Technology in Craniofacial Biology
• Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges
• Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications
• Model Organisms: Opportunities and Challenges in Developmental Physiology
• Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research
• Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research
• Model Organisms and Experimental Models: Opportunities and Challenges in Musculoskeletal Physiology
• Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology
• Experimental Models of Rare Cardiac Diseases

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Editors

Rohit Ramchandra

The University of Auckland

Aisah Aubdool

Queen Mary University of London

Karie Scrogin

Loyola University Chicago

Impact

13,338 Total views

8,920 Article views

3,560 Article downloads

858 Topic views

Published In

Frontiers in Physiology

Integrative Physiology, Respiratory Physiology and Pathophysiology

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