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About this Research Topic

Manuscript Submission Deadline 28 February 2023

Background
Model organisms and experimental models have long been widely used in the field of biosciences, including the area of musculoskeletal physiology. Several important milestones have been achieved in the field thanks to their application, allowing scientists to develop concepts, technologies, and methodologies to better understand physiological processes of the musculoskeletal system also in more complex living systems, including humans.

Understanding the biological, mechanical, and structural mechanisms regulating the development and homeostasis of the musculoskeletal system is essential to studying pathological conditions and contributing to the development of regenerative medicine. Although model organisms cannot fully replicate human conditions and reproduce the clinical pathology of the musculoskeletal system, they play beneficial and vital roles in research for multiple reasons. They provide feasible tools to investigate the mechanism of disease progression instead of the final stages of the pathological tendon conditions that limit human studies. Animal models also reproduce consistent injury models and allow genetic studies, which contribute to the understanding of cellular and molecular mechanisms regulating physiological and pathological musculoskeletal conditions.

Goals
In addition to focusing on the many advantages of using model organisms in the field of musculoskeletal physiology, this Research Topic also aims to shed light on the challenges and limitations that accompany their application. The scope of this collection covers, but is not limited to, the following themes and questions:
- Animal models for tendon development, tendon repair, and chronic tendon diseases
- Animal and experimental models for studying bone physiology and metabolism
- Animal models for cartilage regeneration and repair
- Animal and experimental models to study muscle physiology
- Model systems to study the physiology of joints
- Animal models to better understand the pathophysiology of osteoarthritis and osteoporosis
- Musculoskeletal substitute development and tissue engineering concepts
- Musculoskeletal imaging technologies, and methodologies for assessing musculoskeletal quality and the optimization of musculoskeletal regeneration.

Information for Authors
Several article types will be considered, please find more information here.

This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:

Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges
In Vitro Models: Opportunities and Challenges in Aquatic Physiology
Animal Models and Transgenic Technology in Craniofacial Biology
Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges
Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications
Model Organisms: Opportunities and Challenges in Developmental Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research
Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research
Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology
Experimental Models of Rare Cardiac Diseases

Keywords: musculoskeletal physiology, bone, tendon, ligament, muscle, experimental models, animal models, joints, cartilage, tissue engineering, musculoskeletal regeneration, model organisms, #CollectionSeries


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Background
Model organisms and experimental models have long been widely used in the field of biosciences, including the area of musculoskeletal physiology. Several important milestones have been achieved in the field thanks to their application, allowing scientists to develop concepts, technologies, and methodologies to better understand physiological processes of the musculoskeletal system also in more complex living systems, including humans.

Understanding the biological, mechanical, and structural mechanisms regulating the development and homeostasis of the musculoskeletal system is essential to studying pathological conditions and contributing to the development of regenerative medicine. Although model organisms cannot fully replicate human conditions and reproduce the clinical pathology of the musculoskeletal system, they play beneficial and vital roles in research for multiple reasons. They provide feasible tools to investigate the mechanism of disease progression instead of the final stages of the pathological tendon conditions that limit human studies. Animal models also reproduce consistent injury models and allow genetic studies, which contribute to the understanding of cellular and molecular mechanisms regulating physiological and pathological musculoskeletal conditions.

Goals
In addition to focusing on the many advantages of using model organisms in the field of musculoskeletal physiology, this Research Topic also aims to shed light on the challenges and limitations that accompany their application. The scope of this collection covers, but is not limited to, the following themes and questions:
- Animal models for tendon development, tendon repair, and chronic tendon diseases
- Animal and experimental models for studying bone physiology and metabolism
- Animal models for cartilage regeneration and repair
- Animal and experimental models to study muscle physiology
- Model systems to study the physiology of joints
- Animal models to better understand the pathophysiology of osteoarthritis and osteoporosis
- Musculoskeletal substitute development and tissue engineering concepts
- Musculoskeletal imaging technologies, and methodologies for assessing musculoskeletal quality and the optimization of musculoskeletal regeneration.

Information for Authors
Several article types will be considered, please find more information here.

This Research Topic is part of the Experimental Models and Model Organisms series of Frontiers in Physiology. Other titles in this series include:

Model Organisms and Experimental Models in Membrane Physiology and Membrane Biophysics: Opportunities and Challenges
In Vitro Models: Opportunities and Challenges in Aquatic Physiology
Animal Models and Transgenic Technology in Craniofacial Biology
Experimental Models and Model Organisms in Cardiac Electrophysiology: Opportunities and Challenges
Advances in Pluripotent Stem Cell-Based in Vitro Models of the Human Heart for Cardiac Physiology, Disease Modeling and Clinical Applications
Model Organisms: Opportunities and Challenges in Developmental Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Vascular Physiology Research
Invertebrates as Model Organisms: Opportunities and Challenges in Physiology and Bioscience Research
Model Organisms and Experimental Models: Opportunities and Challenges in Integrative Physiology
Model Organisms and Experimental Models: Opportunities and Challenges in Redox Physiology
Experimental Models of Rare Cardiac Diseases

Keywords: musculoskeletal physiology, bone, tendon, ligament, muscle, experimental models, animal models, joints, cartilage, tissue engineering, musculoskeletal regeneration, model organisms, #CollectionSeries


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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