Type I and type II diabetes, and their associated co-morbidities, represent major global medical and public health concerns, due to their ever-increasing prevalence worldwide as a consequence of factors such as our ageing societies and rates of obesity. Consequently, such situations provide significant economic burdens to healthcare providers within the UK and beyond. One often-overlooked area of clinical concern is how uncontrolled diabetes and the accompanying hyperglycaemia are contributory factors to the initiation and progression of oral-related diseases, in addition to the impact that diabetes has on normal tissue reparative responses within the oral cavity, leading to impaired healing and ensuing clinical complications. Although much is known regarding the cellular changes that mediate diabetes-related disease pathologies and aberrant healing outcomes, our complete understanding of the molecular and cell signalling events that occur, largely remain elusive.Ultimately, we anticipate that this Research Topic will highlight new developments in our understanding of the cellular and molecular events underpinning oral disease progression and attenuated healing in diabetic oral tissues, which may provide novel insights leading to the development of new therapeutic strategies for the prevention or improved treatment of these conditions in future.This Research Topic invites original research and review article contributions that highlight new insights, the challenges and future perspectives into how hyperglycaemic conditions impact on microbial, immuno-inflammatory and resident connective tissue cells during oral disease and impaired healing. We would also welcome studies detailing enhancements in our knowledge of the molecular and cell signalling mechanism changes induced by uncontrolled diabetic conditions, that facilitate oral disease progression and dysfunctional reparative responses. Furthermore, we would encourage manuscripts describing advances in the development of novel therapeutic approaches aimed at addressing the impact of uncontrolled diabetes on oral tissues, leading to the alleviation of disease severity and the re-establishment of repair mechanisms.
Type I and type II diabetes, and their associated co-morbidities, represent major global medical and public health concerns, due to their ever-increasing prevalence worldwide as a consequence of factors such as our ageing societies and rates of obesity. Consequently, such situations provide significant economic burdens to healthcare providers within the UK and beyond. One often-overlooked area of clinical concern is how uncontrolled diabetes and the accompanying hyperglycaemia are contributory factors to the initiation and progression of oral-related diseases, in addition to the impact that diabetes has on normal tissue reparative responses within the oral cavity, leading to impaired healing and ensuing clinical complications. Although much is known regarding the cellular changes that mediate diabetes-related disease pathologies and aberrant healing outcomes, our complete understanding of the molecular and cell signalling events that occur, largely remain elusive.Ultimately, we anticipate that this Research Topic will highlight new developments in our understanding of the cellular and molecular events underpinning oral disease progression and attenuated healing in diabetic oral tissues, which may provide novel insights leading to the development of new therapeutic strategies for the prevention or improved treatment of these conditions in future.This Research Topic invites original research and review article contributions that highlight new insights, the challenges and future perspectives into how hyperglycaemic conditions impact on microbial, immuno-inflammatory and resident connective tissue cells during oral disease and impaired healing. We would also welcome studies detailing enhancements in our knowledge of the molecular and cell signalling mechanism changes induced by uncontrolled diabetic conditions, that facilitate oral disease progression and dysfunctional reparative responses. Furthermore, we would encourage manuscripts describing advances in the development of novel therapeutic approaches aimed at addressing the impact of uncontrolled diabetes on oral tissues, leading to the alleviation of disease severity and the re-establishment of repair mechanisms.